SYNTHESIS OF NOVEL 3-AMINO-2-(1H)-THIOXO-4(3H)-QUINAZOLINONE DERIVATIVES. PART 3

被引：1

作者：

Nawrocka, Wanda ^{[1
]}

Wojcicka, Anna ^{[1
]}

Nowicka, Anna ^{[1
]}

机构：

[1] Wroclaw Med Univ, Dept Drugs Technol, PL-50140 Wroclaw, Poland

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2012年 / 187卷 / 01期

关键词：

Acylation; ammonolysis; 3-amino-2(1H)-thioxo-4(3H)-quinazolinone; 3-amino-2-ethoxy-carbo-nylmethylthio-4(3H)-quinazolinone derivatives; synthesis; 4(3H)-QUINAZOLINONE DERIVATIVES; 3-AMINO-2(1H)-THIOXO-4(3H)-QUINAZOLINONE; ACID;

D O I：

10.1080/10426507.2011.582055

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The synthesis of novel derivatives containing the quinazolinone-4 moiety is described. 3-Amino-2(1H)-tioxo-4(3H)-quinazolinone (1) forms a sodium salt 2, which was subjected to reaction with dicarboxylic acid chlorides such as chloroformyl ethyl formate and malonyl chloride, leading to the corresponding ester 3 and acid 4, respectively. 3-Amino-2-ethoxycarbonylmethylthio-4(3H)-quinazolinone (5) was acylated or ammonolyzed and products of various chemical structure were obtained. The chemical structures 3, 4, 6-12, and 14-18 were identified by the results of elemental analysis and their IR, H-1 NMR, and mass spectra.

引用

页码：79 / 87

页数：9

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