In vitro degradation of β-amyloid[25-35] peptide

被引：1
|
作者：
Jost, K [1 ]
Varga, J [1 ]
Penke, S [1 ]
Zarándi, M [1 ]
机构：
[1] Univ Szeged, Fac Med, Dept Med Chem, H-6720 Szeged, Hungary
来源：
PROTEIN AND PEPTIDE LETTERS | 2001年 / 8卷 / 06期
关键词：
D O I：
10.2174/0929866013409076
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Some amyloid-derived peptides show their toxic effects only after a long "aging" period performed several days at pH 7.4 and 37 degreesC far cluster formation. Our experiments show that long aging of beta -amyloid[25-35] under physiological conditions results in peptide band cleavage between Asn(27) and Lys(28). Relatively short incubation time (24 hours) and absence of Ca2+ ions prevent peptide cleavage and results in good aggregation of beta -amyloids.
引用
收藏
页码：423 / 428
页数：6
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