In vitro degradation of β-amyloid[25-35] peptide

被引：1

作者：

Jost, K ^{[1
]}

Varga, J ^{[1
]}

Penke, S ^{[1
]}

Zarándi, M ^{[1
]}

机构：

[1] Univ Szeged, Fac Med, Dept Med Chem, H-6720 Szeged, Hungary

来源：

PROTEIN AND PEPTIDE LETTERS | 2001年 / 8卷 / 06期

关键词：

D O I：

10.2174/0929866013409076

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Some amyloid-derived peptides show their toxic effects only after a long "aging" period performed several days at pH 7.4 and 37 degreesC far cluster formation. Our experiments show that long aging of beta -amyloid[25-35] under physiological conditions results in peptide band cleavage between Asn(27) and Lys(28). Relatively short incubation time (24 hours) and absence of Ca2+ ions prevent peptide cleavage and results in good aggregation of beta -amyloids.

引用

页码：423 / 428

页数：6

共 50 条

[21] Aggregation studies of β-amyloid 25-35 fragment in interaction with other modified β-amyloid peptide fragments
Frankiewicz, Lukasz P.
Banachewicz, Wiktor
Misicka, Aleksandra
PEPTIDES 2004, PROCEEDINGS: BRIDGES BETWEEN DISCIPLINES, 2005, : 453 - 454
[22] Effects of amyloid beta peptide (25-35) on the behavior of rats in a radial maze
Stepanichev, MY
Moiseeva, YV
Lazareva, NA
Gulyaeva, NV
ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA, 2004, 54 (03) : 382 - 389
[23] A two-dimensional approach to study amyloid β-peptide fragment (25-35)
Triulzi, Robert C.
Li, Changqing
Naistat, David
Orbulescu, Jhony
Leblanc, Roger M.
JOURNAL OF PHYSICAL CHEMISTRY C, 2007, 111 (12): : 4661 - 4666
[24] Insertion of externally administered amyloid β peptide 25-35 and perturbation of lipid bilayers
Dante, S
Hauss, T
Dencher, NA
BIOCHEMISTRY, 2003, 42 (46) : 13667 - 13672
[25] The amyloid β peptide Aβ (25-35) induces apoptosis independent of p53
Blasko, I
Wagner, M
Whitaker, N
Grubeck-Loebenstein, B
Jansen-Dürr, P
FEBS LETTERS, 2000, 470 (02) : 221 - 225
[26] Caloric restriction prevents cognitive impairment induced by β amyloid peptide (25-35)
Hiramatsu, Masayuki
Murai, Chisa
Itoh, Hanako
Nomura, Tomohiro
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2015, 128 (03) : S222 - S222
[27] Potentiation of beta-folding of β-amyloid peptide 25-35 by aluminum salts
Bondy, SC
Truong, A
NEUROSCIENCE LETTERS, 1999, 267 (01) : 25 - 28
[28] Amyloid β-peptide(25-35) changes [Ca2+] in hippocampal neurons
Mogensen, HS
Beatty, DM
Morris, SJ
Jorgensen, OS
NEUROREPORT, 1998, 9 (07) : 1553 - 1558
[29] Molecular dynamics simulations on β amyloid peptide (25-35) in aqueous trifluoroethanol solution
Lee, S
Kim, Y
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2004, 25 (06) : 838 - 842
[30] Genistein ameliorates β-amyloid peptide (25-35)-induced hippocampal neuronal apoptosis
Zeng, HY
Chen, Q
Zhao, BL
FREE RADICAL BIOLOGY AND MEDICINE, 2004, 36 (02) : 180 - 188

← 1 2 3 4 5 →