Effect-site modelling of propofol using auditory evoked potentials

被引:40
作者
White, M
Schenkels, MJ
Engbers, FHM
Vletter, A
Burm, AGL
Bovill, JG
Kenny, GNC
机构
[1] Leiden Univ, Ctr Med, Dept Anaesthesiol, NL-2300 RC Leiden, Netherlands
[2] Univ Glasgow, Dept Anaesthet, Glasgow Royal Infirm, Glasgow, Lanark, Scotland
关键词
anaesthesia; depth; brain; evoked potentials; monitoring; pharmacodynamics; pharmacokinetics; propofol; anaesthetics i.v;
D O I
10.1093/bja/82.3.333
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Auditory evoked potentials (AEP) were used to monitor central nervous system effects during induction and recovery from anaesthesia produced by infusion of propofol 30 mg kg(-1) h(-1) in 22 healthy male patients. Non-parametric and parametric: modelling techniques were used successfully to calculate the parameter k(eo) which linked pharmacokinetic with pharmacodynamic aspects of drug action in only 15 of the study patients. In the non-parametric analysis, k(eo) was found to have a mean value of 0.2 (range 0.1-0.36) min(-1). Estimation of k(eo) allowed calculation of the effect-site concentration (Ce-50) associated with 50% of AEP effect for the population (2.08 mu g ml(-1); 95% confidence limits 1.7-2.45). There were no significant differences between k(eo) values calculated by non-parametric and individual parametric modelling techniques. During recovery, 50% of patients demonstrated evidence of waking at an effect-site concentration of 2.28 mu g ml(-1).
引用
收藏
页码:333 / 339
页数:7
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