Azathioprine-induced EBV-positive mucocutaneous ulcer

被引：41

作者：

McGinness, Jamie L. ^{[1
]}

Spicknall, Kerith E. ^{[1
]}

Mutasim, Diya F. ^{[1
]}

机构：

[1] Univ Cincinnati, Coll Med, Dept Dermatol, Cincinnati, OH 45267 USA

来源：

JOURNAL OF CUTANEOUS PATHOLOGY | 2012年 / 39卷 / 03期

关键词：

azathioprine; EBV; lymphoproliferative disorder; EPSTEIN-BARR-VIRUS; LYMPHOPROLIFERATIVE DISEASE; RHEUMATOID-ARTHRITIS; PATIENT; IMMUNODEFICIENCY; INFECTION; LYMPHOMA; THERAPY;

D O I：

10.1111/j.1600-0560.2011.01829.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Epstein-Barr virus (EBV)-positive mucocutaneous ulcer was recently described as a clinicopathologic entity occurring secondary to iatrogenic or age-related immune suppression. The histopathology of EBV-positive mucocutaneous ulcer reveals a polymorphous infiltrate including atypical large B-cells and Reed-Sternberg-like cells which are CD20-positive, CD30-positive and EBV-positive. The disorder follows an indolent and self-limited course. We report a case of EBV-positive mucocutaneous ulcer secondary to prolonged use of azathioprine for the treatment of pemphigoid and highlight the need for recognition of this disorder by dermatopathologists and dermatologists.

引用

页码：377 / 381

页数：5

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