Azathioprine-induced EBV-positive mucocutaneous ulcer

被引：40
作者：
McGinness, Jamie L. [1 ]
Spicknall, Kerith E. [1 ]
Mutasim, Diya F. [1 ]
机构：
[1] Univ Cincinnati, Coll Med, Dept Dermatol, Cincinnati, OH 45267 USA
来源：
JOURNAL OF CUTANEOUS PATHOLOGY | 2012年 / 39卷 / 03期
关键词：
azathioprine; EBV; lymphoproliferative disorder; EPSTEIN-BARR-VIRUS; LYMPHOPROLIFERATIVE DISEASE; RHEUMATOID-ARTHRITIS; PATIENT; IMMUNODEFICIENCY; INFECTION; LYMPHOMA; THERAPY;
D O I：
10.1111/j.1600-0560.2011.01829.x
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Epstein-Barr virus (EBV)-positive mucocutaneous ulcer was recently described as a clinicopathologic entity occurring secondary to iatrogenic or age-related immune suppression. The histopathology of EBV-positive mucocutaneous ulcer reveals a polymorphous infiltrate including atypical large B-cells and Reed-Sternberg-like cells which are CD20-positive, CD30-positive and EBV-positive. The disorder follows an indolent and self-limited course. We report a case of EBV-positive mucocutaneous ulcer secondary to prolonged use of azathioprine for the treatment of pemphigoid and highlight the need for recognition of this disorder by dermatopathologists and dermatologists.
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页码：377 / 381
页数：5
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