Immunoglobulin light (IgL) chains in ectothermic vertebrates

被引：25
作者：
Edholm, Eva-Stina [1 ]
Wilson, Melanie [1 ]
Bengten, Eva [1 ]
机构：
[1] Univ Mississippi, Med Ctr, Dept Microbiol, Jackson, MS 39216 USA
来源：
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | 2011年 / 35卷 / 09期
关键词：
IgL isotypes; Gene organization; Gene regulation; Ectothermic vertebrates; ANTIBODY REPERTOIRE DEVELOPMENT; TROUT ONCORHYNCHUS-MYKISS; BENCE-JONES PROTEINS; B-CELL DEVELOPMENT; COD GADUS-MORHUA; GENOMIC ORGANIZATION; RAINBOW-TROUT; ALLELIC EXCLUSION; CHANNEL CATFISH; GENE REARRANGEMENTS;
D O I：
10.1016/j.dci.2011.01.012
中图分类号：
S9 [水产、渔业];
学科分类号：
0908 ;
摘要：
Four major ancesteral IgL isotypes have been identified K, X, sigma and sigma-cart. However, depending on the vertebrate class the genomic representation of these isotypes differs in regards to what is encoded in the germline and how these genes are organized. Also, the relative contribution of each isotype in immune responses varies. This review focuses on the IgL chains of ectothermic vertebrates, specifically the number of different isotypes, their phylogenetic relationship, genomic organizations and expression. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：906 / 915
页数：10
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