Application of the Principles of Green Chemistry for the Development of a New and Sensitive Method for Analysis of Ertapenem Sodium by Capillary Electrophoresis

被引：11
作者：
Pedroso, Tahisa Marcela [1 ]
Van Schepdael, Ann [2 ]
Nunes Salgado, Herida Regina [1 ]
机构：
[1] Univ Estadual Paulista, UNESP, Fac Ciencias Farmaceut, Araraquara, SP, Brazil
[2] Univ Leuven, KU Leuven, Dept Pharmaceut & Pharmacol Sci, Pharmaceut Anal, Leuven, Belgium
来源：
INTERNATIONAL JOURNAL OF ANALYTICAL CHEMISTRY | 2019年 / 2019卷
基金：
巴西圣保罗研究基金会;
关键词：
PERFORMANCE LIQUID-CHROMATOGRAPHY; PLACKETT-BURMAN; RP-HPLC; PHARMACEUTICALS; ROBUSTNESS; VALIDATION; STABILITY; OPTIMIZATION; DRUGS; ACID;
D O I：
10.1155/2019/1456313
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
An innovative method is validated for the analysis of ertapenem sodium by capillary electrophoresis using potassium phosphate buffer 10mM pH 7 and 15kV voltage, in the concentration range of 70 to 120gmL(-1). Ertapenem had a migration time of 3.15 minutes and the linearity curve was y = 2281.7 x - 24495 with a R-2 = 0.9994. Thus, we propose a routine analysis method that meets the principles of green analytical chemistry for the routine analysis of ertapenem sodium by capillary electrophoresis.
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页数：11
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