Increased susceptibility to LTP generation and changes in NMDA-NR1 and-NR2B subunits mRNA expression in rat hippocampus after MCH administration

被引：37

作者：

Varas, MM ^{[1
]}

Pérez, MF ^{[1
]}

Ramírez, OA ^{[1
]}

de Barioglio, SR ^{[1
]}

机构：

[1] Univ Nacl Cordoba, Fac Ciencias Quim, Dept Farmacol, RA-5000 Cordoba, Argentina

来源：

PEPTIDES | 2003年 / 24卷 / 09期

关键词：

melanin-concentrating hormone; inhibitory avoidance task; long-term potentiation; expression of NMDA receptor subunits;

D O I：

10.1016/j.peptides.2003.09.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present study attempts to determine which mechanisms underlie the retrograde facilitation of memory induced by microinjection hippocampal melanin-concentrating hormone (MCH) on the inhibitory avoidance paradigm. Previous reports using this test on the hippocampus suggest that NMDA receptor-mediated mechanisms are involved in memory processing and are also necessary for the induction of long-term potentiation (LTP) of the hippocampal dentate gyrus. In addition, alterations in expression of synaptic NMDA subunits in the hippocampus have been associated with memory formation of an inhibitory avoidance task. We have studied the effects of the neuropeptide upon the electrophysiological parameters using hippocampal slices from rats injected with the peptide and tested in step-down tests as well as possible changes in the mRNA expression of NMDA receptor subunits. We postulate that the increased facility to induce UP, and the overexpression of this N-methyl-D-aspartate mRNA receptor subunits induced by MCH, could be behind the retrograde facilitation observed after MCH hippocampal microinjection. (C) 2003 Published by Elsevier Inc.

引用

页码：1403 / 1411

页数：9

共 58 条

[1] THE MELANIN-CONCENTRATING HORMONE SYSTEM OF THE RAT-BRAIN - AN IMMUNIZATION AND HYBRIDIZATION HISTOCHEMICAL CHARACTERIZATION [J].

BITTENCOURT, JC ;

PRESSE, F ;

ARIAS, C ;

PETO, C ;

VAUGHAN, J ;

NAHON, JL ;

VALE, W ;

SAWCHENKO, PE .

JOURNAL OF COMPARATIVE NEUROLOGY, 1992, 319 (02) :218-245

[2] A SYNAPTIC MODEL OF MEMORY - LONG-TERM POTENTIATION IN THE HIPPOCAMPUS [J].

BLISS, TVP ;

COLLINGRIDGE, GL .

NATURE, 1993, 361 (6407) :31-39

[3] The human hippocampus and spatial and episodic memory [J].

Burgess, N ;

Maguire, EA ;

O'Keefe, J .

NEURON, 2002, 35 (04) :625-641

[4] Mechanisms of emotional arousal and lasting declarative memory [J].

Cahill, L ;

McGaugh, JL .

TRENDS IN NEUROSCIENCES, 1998, 21 (07) :294-299

[5] Rapid and transient learning-associated increase in NMDA NR1 subunit in the rat hippocampus [J].

Cammarota, M ;

de Stein, ML ;

Paratcha, G ;

Bevilaqua, LRM ;

Izquierdo, I ;

Medina, JH .

NEUROCHEMICAL RESEARCH, 2000, 25 (05) :567-572

[6] Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1 [J].

Chambers, J ;

Ames, RS ;

Bergsma, D ;

Muir, A ;

Fitzgerald, LR ;

Hervieu, G ;

Dytko, GM ;

Foley, JJ ;

Martin, J ;

Liu, WS ;

Park, J ;

Ellis, C ;

Ganguly, S ;

Konchar, S ;

Cluderay, J ;

Leslie, R ;

Wilson, S ;

Sarau, HM .

NATURE, 1999, 400 (6741) :261-265

[7] Subtype-dependence of NMDA receptor channel open probability [J].

Chen, NS ;

Luo, T ;

Raymond, LA .

JOURNAL OF NEUROSCIENCE, 1999, 19 (16) :6844-6854

[8] LONG-TERM POTENTIATION IN THE HIPPOCAMPUS - MECHANISMS OF INITIATION AND MODULATION BY NEUROTRANSMITTERS [J].

COLLINGRIDGE, GL .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1985, 6 (10) :407-411

[9] MEMORIES OF NMDA RECEPTORS AND LTP [J].

COLLINGRIDGE, GL ;

BLISS, TVP .

TRENDS IN NEUROSCIENCES, 1995, 18 (02) :54-56

[10] EXCITATORY AMINO-ACIDS IN SYNAPTIC TRANSMISSION IN THE SCHAFFER COLLATERAL COMMISSURAL PATHWAY OF THE RAT HIPPOCAMPUS [J].

COLLINGRIDGE, GL ;

KEHL, SJ ;

MCLENNAN, H .

JOURNAL OF PHYSIOLOGY-LONDON, 1983, 334 (JAN) :33-46

← 1 2 3 4 5 6 →