Regulation of Glucose Transport in Adipocytes by Interleukin-4

被引:4
作者
Michurina, Svetlana [1 ,2 ]
Stafeev, Iurii [1 ]
Beloglazova, Irina [1 ]
Zubkova, Ekaterina [1 ]
Mamontova, Elizaveta [1 ,3 ]
Kopylov, Artur [4 ,5 ]
Shevchenko, Eugene [1 ]
Menshikov, Mikhail [1 ]
Parfyonova, Yelena [1 ,3 ]
机构
[1] Natl Med Res Ctr Cardiol, Moscow 121552, Russia
[2] Lomonosov Moscow State Univ, Dept Biochem, Moscow, Russia
[3] Lomonosov Moscow State Univ, Dept Biochem & Mol Med, Moscow, Russia
[4] Inst Biomed Chem, Moscow, Russia
[5] Inst Gen Pathol & Pathophysiol, Moscow, Russia
关键词
interleukin-4; STAT6; adipocyte; mitochondria; insulin resistance; inflammation; INSULIN SENSITIVITY; MACROPHAGES; METABOLISM; DIFFERENTIATION; EOSINOPHILS; ACTIVATION; CELLS;
D O I
10.1089/jir.2021.0213
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Metabolic abnormalities such as obesity, insulin resistance, and type 2 diabetes mellitus are known to be associated with adipose tissue inflammation and impaired secretion of cytokines. Anti-inflammatory cytokine interleukin-4 (IL-4) was found to promote insulin sensitivity, glucose tolerance, and reduce lipid accumulation in vivo through multiple mechanisms, including direct regulation of lipolysis in adipocytes. However, little is known about its role in adipocyte glucose metabolism. This study reveals that IL-4 upregulates glucose uptake in adipocytes without additional activation of the insulin-dependent IRS1 (insulin receptor substrate 1)-Akt (protein kinase B) pathway. Moreover, the main transcription factor STAT6 (signal transducer and activator of transcription 6), regulated by IL-4, was not involved in adipocyte glucose uptake. The proteomic results showed that IL-4 upregulates expression of proteins involved in mitochondrial biogenesis, renewal, and glucose oxidation. Our study provides a new hypothesis, explaining protective effects of IL-4 against metabolic abnormalities through activation of adipocytes glucose utilization and maintenance of mitochondrial function under metabolic overload conditions.
引用
收藏
页码:127 / 136
页数:10
相关论文
共 37 条
[21]   IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity [J].
Ricardo-Gonzalez, Roberto R. ;
Eagle, Alex Red ;
Odegaard, Justin I. ;
Jouihan, Hani ;
Morel, Christine R. ;
Heredia, Jose E. ;
Mukundan, Lata ;
Wu, Davina ;
Locksley, Richard M. ;
Chawla, Ajay .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (52) :22617-22622
[22]   The transcriptional response of mouse spleen B cells to IL-4: Comparison to the response of human peripheral blood B cells [J].
Ruiz-Lafuente, Natalia ;
Muro, Manuel ;
Minguela, Alfredo ;
Parrado, Antonio .
BIOCHEMISTRY AND BIOPHYSICS REPORTS, 2018, 16 :56-61
[23]   The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity [J].
Shan, Bo ;
Wang, Xiaoxia ;
Wu, Ying ;
Xu, Chi ;
Xia, Zhixiong ;
Dai, Jianli ;
Shao, Mengle ;
Zhao, Feng ;
He, Shengqi ;
Yang, Liu ;
Zhang, Mingliang ;
Nan, Fajun ;
Li, Jia ;
Liu, Jianmiao ;
Liu, Jianfeng ;
Jia, Weiping ;
Qiu, Yifu ;
Song, Baoliang ;
Han, Jing-Dong J. ;
Rui, Liangyou ;
Duan, Sheng-Zhong ;
Liu, Yong .
NATURE IMMUNOLOGY, 2017, 18 (05) :519-529
[24]   Mechanism of Interleukin-4 Reducing Lipid Deposit by Regulating Hormone-Sensitive Lipase [J].
Shiau, Ming-Yuh ;
Chuang, Pei-Hua ;
Yang, Ching-Ping ;
Hsiao, Chiao-Wan ;
Chang, Shu-Wen ;
Chang, Kai-Yun ;
Liu, Tsung-Ming ;
Chen, Huan-Wen ;
Chuang, Cheng-Chieh ;
Yuan, Sheau-Yun ;
Chang, Yih-Hsin .
SCIENTIFIC REPORTS, 2019, 9 (1)
[25]   Characterization of proteins regulated by interleukin-4 in 3T3-L1 adipocytes [J].
Shiau, Ming-Yuh ;
Lu, Hsu-Feng ;
Chang, Yih-Hsin ;
Chiu, Yen-Chih ;
Shih, Yung-Luen .
SPRINGERPLUS, 2015, 4
[26]  
Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
[27]   Interleukin-4 Restores Insulin Sensitivity in Lipid-Induced Insulin-Resistant Adipocytes [J].
Stafeev, I. S. ;
Michurina, S. S. ;
Podkuychenko, N. V. ;
Vorotnikov, A. V. ;
Menshikov, M. Yu. ;
Parfyonova, Ye. V. .
BIOCHEMISTRY-MOSCOW, 2018, 83 (05) :498-506
[28]   Identification of a Prognostic Hypoxia-Associated Gene Set in IDH-Mutant Glioma [J].
Trong, Philip Dao ;
Roesch, Saskia ;
Mairbaeurl, Heimo ;
Pusch, Stefan ;
Unterberg, Andreas ;
Herold-Mende, Christel ;
Warta, Rolf .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (10)
[29]   Interleukin-4 regulates lipid metabolism by inhibiting adipogenesis and promoting lipolysis [J].
Tsao, Chang-Hui ;
Shiau, Ming-Yuh ;
Chuang, Pei-Hua ;
Chang, Yih-Hsin ;
Hwang, Jaulang .
JOURNAL OF LIPID RESEARCH, 2014, 55 (03) :385-397
[30]   Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor [J].
Wei, Yongjie ;
Chiang, Wei-Chung ;
Sumpter, Rhea, Jr. ;
Mishra, Prashant ;
Levine, Beth .
CELL, 2017, 168 (1-2) :224-+