Antibodies against alpha-fodrin in Sjogren's syndrome

被引：28

作者：

Ulbricht, KU ^{[1
]}

Schmidt, RE ^{[1
]}

Witte, T ^{[1
]}

机构：

[1] Hannover Med Sch, Abt Klin Immunol, D-30625 Hannover, Germany

来源：

AUTOIMMUNITY REVIEWS | 2003年 / 2卷 / 02期

关键词：

Sjogren's syndrome; alpha-fodrin; apoptosis; autoantibodies;

D O I：

10.1016/S1568-9972(03)00002-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Alpha-fodrin is a part of the membrane skeleton and expressed in the majority of mammalian cells. It is cleaved in apoptosis by caspase 3. One of the cleavage products, a 120-kDa protein, represents a neoantigen. Antibodies against that cleavage product of alpha-fodrin have originally been described in a murine model of Sjogren's syndrome. In addition, they are also present in up to 93% of patients with Sjogren's syndrome, depending on the stringency of the classification used. Although antibodies against alpha-fodrin are observed in other diseases characterized by chronic apoptosis, they are a valuable laboratory marker in the evaluation of Sjogren's syndrome. (C) 2002 Elsevier Science B.V. rights reserved.

引用

页码：109 / 113

页数：5

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