Anti-human leukocyte antigen DQ antibodies in renal transplantation: Are we underestimating the most frequent donor specific alloantibodies?

被引：11

作者：

Carta, Paolo ^{[1
]}

Di Maria, Lorenzo ^{[1
]}

Caroti, Leonardo ^{[1
]}

Buti, Elisa ^{[1
]}

Antognoli, Giulia ^{[1
]}

Minetti, Enrico Eugenio ^{[1
]}

机构：

[1] Careggi Univ Hosp, Nephrol Unit, I-50134 Florence, Italy

来源：

TRANSPLANTATION REVIEWS | 2015年 / 29卷 / 03期

关键词：

HLA-SPECIFIC ANTIBODIES; CLINICAL-RELEVANCE; KIDNEY-TRANSPLANTATION; MEDIATED REJECTION; PREDICTOR; IMPACT;

D O I：

10.1016/j.trre.2015.04.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The role of anti-human leukocyte antigens DQ region (HLA-DQ) in transplantation is historically less studied than HLA-DR and HLA class I regions, but several studies are demonstrating that anti HLA-DQ antibodies are among the most frequent anti HLA antibodies that develop after transplantation and can have great influence on the developing of humoral rejection and graft loss. In this article we review the gene structure and nomenclature of the HLA-DQ region, the role of anti HIA-DQ antibodies after and before transplantation and briefly the associations of particular HIA-DQ alleles and other diseases. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：135 / 138

页数：4

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