Viral resistance in HCV infection

被引：14

作者：

Ceccherini-Silberstein, Francesca ^{[1
]}

Cento, Valeria ^{[2
]}

Di Maio, Velia Chiara ^{[1
]}

Perno, Carlo Federico ^{[3
]}

Craxi, Antonio ^{[4
]}

机构：

[1] Univ Roma Tor Vergata, Dept Expt Med, Via Montpellier 1, I-00133 Rome, Italy

[2] Univ Milan, Residency Program Microbiol & Virol, Via Festa del Perdono 7, I-20122 Milan, Italy

[3] Univ Milan, Dept Oncol & Oncohematol, Via Festa del Perdono 7, I-20122 Milan, Italy

[4] P Giaccone Univ Hosp Palermo, Gastroenterol, Piazza Clin 2, I-90127 Palermo, Italy

来源：

CURRENT OPINION IN VIROLOGY | 2018年 / 32卷

关键词：

C VIRUS-INFECTION; DACLATASVIR PLUS SOFOSBUVIR; GENOTYPE; INFECTION; HEPATITIS-C; GLOBAL EPIDEMIOLOGY; ANTIVIRAL AGENTS; PREVALENCE; NS5A; POLYMORPHISMS; SUBSTITUTIONS;

D O I：

10.1016/j.coviro.2018.10.005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The introduction of new multi-genotypic direct acting antivirals (DAA) in clinical practice has revolutionized HCV treatment, permitting the achievement of >95% rates of sustained virological response in many patients. However, virological failures can occur particularly if the treatments are sub optimal and/or with too short duration. Failure is often associated with development of resistance. The wide genetic variability in terms of different genotypes and subtypes, together with the natural presence and/or easy development of resistance during treatment, are intrinsic characteristics of HCV that may affect the treatment outcome and the chances of achieving a virological cure. This review explores in detail the aspects of HCV innate and treatment-induced resistance to new interferon-free DAA regimens.

引用

页码：115 / 127

页数：13

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