First Acid-Catalyzed Entry to O-Alkylated Hydroximides from Benzylic Alcohols

被引：19

作者：

Reddy, Chada Raji ^{[1
]}

Radhika, Laghuvarapu ^{[1
]}

Kumar, Togapur Pavan ^{[1
]}

Chandrasekhar, Srivari ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Organ Chem Div NPL 1, Hyderabad 500607, Andhra Pradesh, India

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 2011卷 / 30期

关键词：

Alkylation; Acid catalysis; Heterocycles; Alcohols; CHIRAL ALPHA-(AMINOOXY)ARYLACETIC ESTER; NUCLEOPHILIC-SUBSTITUTION; PROPARGYLIC ALCOHOLS; AMINOXY ACIDS; OXIME ETHERS; PEPTIDES; DERIVATIVES; ROUTE; TRANSFORMATION; EFFICIENT;

D O I：

10.1002/ejoc.201100797

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile method for the synthesis of O-alkylated hydroximides through the acid-catalyzed alkylation of hydroximides by using benzylic alcohols as alkylating agents is described for the first time. The obtained O-propargylated products offered easy access to 2,5-and 4,5-dihydroisoxazoles.

引用

页码：5967 / 5970

页数：4

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