Recent Advancements on Benzimidazole: A Versatile Scaffold in Medicinal Chemistry

被引：43
作者：
Alzhrani, Zohor Mohammad Mahdi [1 ]
Alam, Mohammad Mahboob [1 ]
Nazreen, Syed [1 ]
机构：
[1] Univ Alberta, Fac Sci, Dept Chem, Edmonton, AB, Canada
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2022年 / 22卷 / 02期
关键词：
Benzimidazole; anticancer; antimicrobial; anti-inflammatory; antitubercular; synthesis; NEWLY SYNTHESIZED BENZIMIDAZOLE; ONE-POT SYNTHESIS; MICROWAVE-ASSISTED SYNTHESIS; SOLVENT-FREE SYNTHESIS; BIOLOGICAL EVALUATION; IN-VITRO; ANTICANCER ACTIVITY; MOLECULAR DOCKING; ALPHA-GLUCOSIDASE; EFFICIENT SYNTHESIS;
D O I：
10.2174/1389557521666210331163810
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Benzimidazole is a nitrogen-containing fused heterocycle which has been extensively explored in medicinal chemistry. Benzimidizole nucleus has been found to possess various biological activities such as anticancer, antimicrobial, anti-inflammatory, antiviral, antitubercular and antidiabetic. A number of benzimidazoles such as bendamustine, pantoprazole have been approved for the treatment of various illnesses, whereas galeterone and GSK461364 are in clinical trials. The present review article gives an overview of the different biological activities exhibited by the benzimidazole derivatives as well as different methods used for the synthesis of benzimidazole derivatives in the past ten years.
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页码：365 / 386
页数：22
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