Recent Advancements on Benzimidazole: A Versatile Scaffold in Medicinal Chemistry

被引：43

作者：

Alzhrani, Zohor Mohammad Mahdi ^{[1
]}

Alam, Mohammad Mahboob ^{[1
]}

Nazreen, Syed ^{[1
]}

机构：

[1] Univ Alberta, Fac Sci, Dept Chem, Edmonton, AB, Canada

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2022年 / 22卷 / 02期

关键词：

Benzimidazole; anticancer; antimicrobial; anti-inflammatory; antitubercular; synthesis; NEWLY SYNTHESIZED BENZIMIDAZOLE; ONE-POT SYNTHESIS; MICROWAVE-ASSISTED SYNTHESIS; SOLVENT-FREE SYNTHESIS; BIOLOGICAL EVALUATION; IN-VITRO; ANTICANCER ACTIVITY; MOLECULAR DOCKING; ALPHA-GLUCOSIDASE; EFFICIENT SYNTHESIS;

D O I：

10.2174/1389557521666210331163810

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Benzimidazole is a nitrogen-containing fused heterocycle which has been extensively explored in medicinal chemistry. Benzimidizole nucleus has been found to possess various biological activities such as anticancer, antimicrobial, anti-inflammatory, antiviral, antitubercular and antidiabetic. A number of benzimidazoles such as bendamustine, pantoprazole have been approved for the treatment of various illnesses, whereas galeterone and GSK461364 are in clinical trials. The present review article gives an overview of the different biological activities exhibited by the benzimidazole derivatives as well as different methods used for the synthesis of benzimidazole derivatives in the past ten years.

引用

页码：365 / 386

页数：22

共 169 条

[11] Synthetic approaches to benzimidazoles from O-phenylenediamine: A literature review [J].

Alaqeel, Shatha Ibrahim .

JOURNAL OF SAUDI CHEMICAL SOCIETY, 2017, 21 (02) :229-237

[12] Synthesis, Characterization and Cytotoxic Study of 2-Hydroxy Benzothiazole Incorporated 1,3,4-Oxadiazole Derivatives [J].

Alghamdi, Afnan A. ;

Nazreen, Syed .

EGYPTIAN JOURNAL OF CHEMISTRY, 2020, 63 (02) :471-482

[13] Design, synthesis and in vitro antiproliferative activity of new thiazolidinedione-1,3,4-oxadiazole hybrids as thymidylate synthase inhibitors [J].

Alzhrani, Zohor Mohammad Mahdi ;

Alam, Mohammad Mahboob ;

Neamatallah, Thikryat ;

Nazreen, Syed .

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2020, 35 (01) :1116-1123

[14]

Aniket P., 2015, Int. J. ChemTech Res, V8, P496

[15] Novel coumarin benzimidazole derivatives as antioxidants and safer anti-inflammatory agents [J].

Arora, Radha Krishan ;

Kaur, Navneet ;

Bansal, Yogita ;

Bansal, Gulshan .

ACTA PHARMACEUTICA SINICA B, 2014, 4 (05) :368-375

[16] 5-Bromo-2-aryl benzimidazole derivatives as non-cytotoxic potential dual inhibitors of α-glucosidase and urease enzymes [J].

Arshad, Tanzila ;

Khan, Khalid Mohammed ;

Rasool, Najma ;

Salar, Uzma ;

Hussain, Shafqat ;

Asghar, Humna ;

Ashraf, Mohammed ;

Wadood, Abdul ;

Riaz, Muhammad ;

Perveen, Shahnaz ;

Taha, Muhammad ;

Ismail, Nor Hadiani .

BIOORGANIC CHEMISTRY, 2017, 72 :21-31

[17] Facile protocol for the synthesis of benzothiazole, benzoxazole and N-benzimidazole derivatives using rice husk derived chemically activated carbon [J].

Asatkar, Archana ;

Lambat, Trimurti L. ;

Mahmood, Sami ;

Mondal, Aniruddha ;

Singh, Man ;

Banerjee, Subhash .

MATERIALS TODAY-PROCEEDINGS, 2020, 29 :738-742

[18] Synthesis and biological evaluation of new benzimidazole-1,2,3-triazole hybrids as potential α-glucosidase inhibitors [J].

Asemanipoor, Nafise ;

Mohammadi-Khanaposhtani, Maryam ;

Moradi, Shahram ;

Vahidi, Mahbobeh ;

Asadi, Mehdi ;

Faramarzi, Mohammad Ali ;

Mahdavi, Mohammad ;

Biglar, Mahmood ;

Larijani, Bagher ;

Hamedifar, Haleh ;

Hajimiri, Mir Hamed .

BIOORGANIC CHEMISTRY, 2020, 95

[19] Novel benzimidazole derivatives: Synthesis, in vitro cytotoxicity, apoptosis and cell cycle studies [J].

Atmaca, Harika ;

Ilhan, Suleyman ;

Batir, Muhammet Burak ;

Pulat, Cisil Camli ;

Guner, Adem ;

Bektas, Hakan .

CHEMICO-BIOLOGICAL INTERACTIONS, 2020, 327

[20] SAR Studies on Trisubstituted Benzimidazoles as Inhibitors of Mtb FtsZ for the Development of Novel Antitubercular Agents [J].

Awasthi, Divya ;

Kumar, Kunal ;

Knudson, Susan E. ;

Slayden, Richard A. ;

Ojima, Iwao .

JOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (23) :9756-9770

← 1 2 3 4 5 6 7 8 9 10 →