Recent Advancements on Benzimidazole: A Versatile Scaffold in Medicinal Chemistry

被引：43

作者：

Alzhrani, Zohor Mohammad Mahdi ^{[1
]}

Alam, Mohammad Mahboob ^{[1
]}

Nazreen, Syed ^{[1
]}

机构：

[1] Univ Alberta, Fac Sci, Dept Chem, Edmonton, AB, Canada

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2022年 / 22卷 / 02期

关键词：

Benzimidazole; anticancer; antimicrobial; anti-inflammatory; antitubercular; synthesis; NEWLY SYNTHESIZED BENZIMIDAZOLE; ONE-POT SYNTHESIS; MICROWAVE-ASSISTED SYNTHESIS; SOLVENT-FREE SYNTHESIS; BIOLOGICAL EVALUATION; IN-VITRO; ANTICANCER ACTIVITY; MOLECULAR DOCKING; ALPHA-GLUCOSIDASE; EFFICIENT SYNTHESIS;

D O I：

10.2174/1389557521666210331163810

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Benzimidazole is a nitrogen-containing fused heterocycle which has been extensively explored in medicinal chemistry. Benzimidizole nucleus has been found to possess various biological activities such as anticancer, antimicrobial, anti-inflammatory, antiviral, antitubercular and antidiabetic. A number of benzimidazoles such as bendamustine, pantoprazole have been approved for the treatment of various illnesses, whereas galeterone and GSK461364 are in clinical trials. The present review article gives an overview of the different biological activities exhibited by the benzimidazole derivatives as well as different methods used for the synthesis of benzimidazole derivatives in the past ten years.

引用

页码：365 / 386

页数：22

共 169 条

[91] Design, synthesis, in silico molecular docking and biological evaluation of novel oxadiazole based thiazolidine-2,4-diones bis-heterocycles as PPAR-γ agonists [J].

Nazreen, Syed ;

Alam, Mohammad Sarwar ;

Hamid, Hinna ;

Yar, Mohammad Shahar ;

Shafi, Syed ;

Dhulap, Abhijeet ;

Alam, Perwez ;

Pasha, M. A. Q. ;

Bano, Sameena ;

Alam, Mohammad Mahboob ;

Haider, Saglain ;

Ali, Yakub ;

Kharbanda, Chetna ;

Pillai, K. K. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 87 :175-185

[92]

Nofal ZM, 2011, ACTA POL PHARM, V68, P519

[93] Synthesis, characterization, anti-ulcer action and molecular docking evaluation of novel benzimidazole-pyrazole hybrids [J].

Noor, Abida ;

Qazi, Neelum Gul ;

Nadeem, Humaira ;

Khan, Arif-ullah ;

Paracha, Rehan Zafar ;

Ali, Fawad ;

Saeed, Adil .

CHEMISTRY CENTRAL JOURNAL, 2017, 11

[94] A simple and efficient synthesis of benzimidazoles containing piperazine or morpholine skeleton at C-6 position as glucosidase inhibitors with antioxidant activity [J].

Ozil, Musa ;

Parlak, Cansu ;

Baltas, Nimet .

BIOORGANIC CHEMISTRY, 2018, 76 :468-477

[95] A simple and efficient synthesis of novel inhibitors of alpha-glucosidase based on benzimidazole skeleton and molecular docking studies [J].

Ozil, Musa ;

Emirik, Mustafa ;

Etlik, Semiha Yilmaz ;

Ulker, Serdar ;

Kahveci, Bahittin .

BIOORGANIC CHEMISTRY, 2016, 68 :226-235

[96] Antimicrobial Activity of a New Series of Benzimidazole Derivatives [J].

Ozkay, Yusuf ;

Tunali, Yagmur ;

Karaca, Hulya ;

Isikdag, Ilhan .

ARCHIVES OF PHARMACAL RESEARCH, 2011, 34 (09) :1427-1435

[97] The GSK461364 PLK1 inhibitor exhibits strong antitumoral activity in preclinical neuroblastoma models [J].

Pajtler, Kristian W. ;

Sadowski, Natalie ;

Ackermann, Sandra ;

Althoff, Kristina ;

Schoenbeck, Kerstin ;

Batzke, Katharina ;

Schaefers, Simon ;

Odersky, Andrea ;

Heukamp, Lukas ;

Astrahantseff, Kathy ;

Kuenkele, Annette ;

Deubzer, Hedwig E. ;

Schramm, Alexander ;

Spruessel, Annika ;

Thor, Theresa ;

Lindner, Sven ;

Eggert, Angelika ;

Fischer, Matthias ;

Schulte, Johannes H. .

ONCOTARGET, 2017, 8 (04) :6730-6741

[98]

Pardeshi S. D., 2015, INT J CHEM PHYS SCI, V4, P300

[99] Antibacterial and antifungal screening of newly synthesized benzimidazole-clubbed chalcone derivatives [J].

Parikh, Kalpesh ;

Joshi, Deepkumar .

MEDICINAL CHEMISTRY RESEARCH, 2013, 22 (08) :3688-3697

[100] Design, synthesis and evaluation of novel 2,5,6-trisubstituted benzimidazoles targeting FtsZ as antitubercular agents [J].

Park, Bora ;

Awasthi, Divya ;

Chowdhury, Soumya R. ;

Melief, Eduard H. ;

Kumar, Kunal ;

Knudson, Susan E. ;

Slayden, Richard A. ;

Ojima, Iwao .

BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 22 (09) :2602-2612

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