A Comparison of the Arterial Blood Concentration of Isoflurane During Cardiopulmonary Bypass Between 2 Polypropylene Oxygenators

被引:4
作者
Alston, R. Peter [1 ]
Kitchen, Cathy [2 ]
McKenzie, Christopher [1 ]
Homer, Natalie [3 ]
机构
[1] Royal Infirm Edinburgh NHS Trust, Dept Anaesthesia Crit Care & Pain Med, 51 Little France Crescent, Edinburgh EH16 4SA, Midlothian, Scotland
[2] Univ Edinburgh, Sch Med & Vet Med, Edinburgh, Midlothian, Scotland
[3] Univ Edinburgh, Clin Res Facil Mass Spectrometry Core Ctr Cardiov, Queens Med Res Inst, Edinburgh, Midlothian, Scotland
关键词
anesthesia; isoflurane; oxygenator; cardiopulmonary bypass; heart surgery; BISPECTRAL INDEX; ANESTHESIA; AWARENESS; ELIMINATION; DIFFUSION; GAS;
D O I
10.1053/j.jvca.2019.08.023
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Objective: The primary objective was to compare arterial blood concentration of isoflurane during cardiopulmonary bypass (CPB) between 2 polypropylene oxygenators of different designs. Secondary objectives were to compare levels of Bispectral Index Score (BIS) during CPB between the 2 oxygenators and to examine the relationships between oxygenator exhaust and arterial blood concentrations of isoflurane and BIS. Design: Single, blinded, randomized control trial. Setting: Teaching hospital. Participants: Twenty-five patients undergoing cardiac surgery with CPB. Interventions: Subjects were randomly assigned (1:1) to Inspire 8F (Sorin) or Affinity Fusion (Medtronic) oxygenators. Measurements and Main Results: The mean arterial blood concentration in the Inspire 8F (Sorin) group was 59 (standard deviation [SD] 23) mu g/mL, compared with 53 (SD 17) mu g/mL in the Affinity Fusion (Medtronic) group with a nonsignificant mean difference of 6 (95% confidence interval = -11, 22) mu g/mL (t[23] = 0.676, p = 0.50). No significant difference in BIS was found between the groups (p = 0.896). Moderate and strong, negative correlations respectively, were found between arterial and oxygenator exhaust correlations and BIS (r = -0.472, p < 0.05; r = -0.812, p < 0.001). A strong, positive correlation was found between arterial and exhaust isoflurane concentration (r = 0.810, p < 0.0005). Conclusions: No significant difference in arterial blood concentration of isoflurane or BIS was found between the Inspire 8F (Sorin) and Affinity Fusion (Medtronic) oxygenators. A significant positive correlation was found between arterial blood and oxygenator exhaust concentrations of isoflurane, as well as significant negative correlations between both arterial and oxygenator exhaust concentrations of isoflurane and BIS. Crown Copyright (C) 2019 Published by Elsevier Inc. All rights reserved.
引用
收藏
页码:1184 / 1190
页数:7
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