Objective: The primary objective was to compare arterial blood concentration of isoflurane during cardiopulmonary bypass (CPB) between 2 polypropylene oxygenators of different designs. Secondary objectives were to compare levels of Bispectral Index Score (BIS) during CPB between the 2 oxygenators and to examine the relationships between oxygenator exhaust and arterial blood concentrations of isoflurane and BIS. Design: Single, blinded, randomized control trial. Setting: Teaching hospital. Participants: Twenty-five patients undergoing cardiac surgery with CPB. Interventions: Subjects were randomly assigned (1:1) to Inspire 8F (Sorin) or Affinity Fusion (Medtronic) oxygenators. Measurements and Main Results: The mean arterial blood concentration in the Inspire 8F (Sorin) group was 59 (standard deviation [SD] 23) mu g/mL, compared with 53 (SD 17) mu g/mL in the Affinity Fusion (Medtronic) group with a nonsignificant mean difference of 6 (95% confidence interval = -11, 22) mu g/mL (t[23] = 0.676, p = 0.50). No significant difference in BIS was found between the groups (p = 0.896). Moderate and strong, negative correlations respectively, were found between arterial and oxygenator exhaust correlations and BIS (r = -0.472, p < 0.05; r = -0.812, p < 0.001). A strong, positive correlation was found between arterial and exhaust isoflurane concentration (r = 0.810, p < 0.0005). Conclusions: No significant difference in arterial blood concentration of isoflurane or BIS was found between the Inspire 8F (Sorin) and Affinity Fusion (Medtronic) oxygenators. A significant positive correlation was found between arterial blood and oxygenator exhaust concentrations of isoflurane, as well as significant negative correlations between both arterial and oxygenator exhaust concentrations of isoflurane and BIS. Crown Copyright (C) 2019 Published by Elsevier Inc. All rights reserved.
机构:
Hammersmith Hosp, Div Surg Anaesthesia & Intens Care, London W12 0HS, EnglandHammersmith Hosp, Div Surg Anaesthesia & Intens Care, London W12 0HS, England
Lockwood, GG
;
Sapsed-Byrne, SM
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Hammersmith Hosp, Div Surg Anaesthesia & Intens Care, London W12 0HS, EnglandHammersmith Hosp, Div Surg Anaesthesia & Intens Care, London W12 0HS, England
Sapsed-Byrne, SM
;
Adams, S
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Hammersmith Hosp, Div Surg Anaesthesia & Intens Care, London W12 0HS, EnglandHammersmith Hosp, Div Surg Anaesthesia & Intens Care, London W12 0HS, England
机构:
Duke Univ, Med Ctr, Dept Anesthesiol, Div Cardiothorac Anesthesiol & Crit Care, Durham, NC 27710 USADuke Univ, Med Ctr, Dept Anesthesiol, Div Cardiothorac Anesthesiol & Crit Care, Durham, NC 27710 USA
Mathew, JP
;
Weatherwax, KJ
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Duke Univ, Med Ctr, Dept Anesthesiol, Div Cardiothorac Anesthesiol & Crit Care, Durham, NC 27710 USADuke Univ, Med Ctr, Dept Anesthesiol, Div Cardiothorac Anesthesiol & Crit Care, Durham, NC 27710 USA
Weatherwax, KJ
;
East, CJ
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Duke Univ, Med Ctr, Dept Anesthesiol, Div Cardiothorac Anesthesiol & Crit Care, Durham, NC 27710 USADuke Univ, Med Ctr, Dept Anesthesiol, Div Cardiothorac Anesthesiol & Crit Care, Durham, NC 27710 USA
East, CJ
;
White, WD
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Duke Univ, Med Ctr, Dept Anesthesiol, Div Cardiothorac Anesthesiol & Crit Care, Durham, NC 27710 USADuke Univ, Med Ctr, Dept Anesthesiol, Div Cardiothorac Anesthesiol & Crit Care, Durham, NC 27710 USA
White, WD
;
Reves, J
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Duke Univ, Med Ctr, Dept Anesthesiol, Div Cardiothorac Anesthesiol & Crit Care, Durham, NC 27710 USADuke Univ, Med Ctr, Dept Anesthesiol, Div Cardiothorac Anesthesiol & Crit Care, Durham, NC 27710 USA
机构:
Hammersmith Hosp, Div Surg Anaesthesia & Intens Care, London W12 0HS, EnglandHammersmith Hosp, Div Surg Anaesthesia & Intens Care, London W12 0HS, England
Lockwood, GG
;
Sapsed-Byrne, SM
论文数: 0引用数: 0
h-index: 0
机构:
Hammersmith Hosp, Div Surg Anaesthesia & Intens Care, London W12 0HS, EnglandHammersmith Hosp, Div Surg Anaesthesia & Intens Care, London W12 0HS, England
Sapsed-Byrne, SM
;
Adams, S
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h-index: 0
机构:
Hammersmith Hosp, Div Surg Anaesthesia & Intens Care, London W12 0HS, EnglandHammersmith Hosp, Div Surg Anaesthesia & Intens Care, London W12 0HS, England
机构:
Duke Univ, Med Ctr, Dept Anesthesiol, Div Cardiothorac Anesthesiol & Crit Care, Durham, NC 27710 USADuke Univ, Med Ctr, Dept Anesthesiol, Div Cardiothorac Anesthesiol & Crit Care, Durham, NC 27710 USA
Mathew, JP
;
Weatherwax, KJ
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h-index: 0
机构:
Duke Univ, Med Ctr, Dept Anesthesiol, Div Cardiothorac Anesthesiol & Crit Care, Durham, NC 27710 USADuke Univ, Med Ctr, Dept Anesthesiol, Div Cardiothorac Anesthesiol & Crit Care, Durham, NC 27710 USA
Weatherwax, KJ
;
East, CJ
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h-index: 0
机构:
Duke Univ, Med Ctr, Dept Anesthesiol, Div Cardiothorac Anesthesiol & Crit Care, Durham, NC 27710 USADuke Univ, Med Ctr, Dept Anesthesiol, Div Cardiothorac Anesthesiol & Crit Care, Durham, NC 27710 USA
East, CJ
;
White, WD
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h-index: 0
机构:
Duke Univ, Med Ctr, Dept Anesthesiol, Div Cardiothorac Anesthesiol & Crit Care, Durham, NC 27710 USADuke Univ, Med Ctr, Dept Anesthesiol, Div Cardiothorac Anesthesiol & Crit Care, Durham, NC 27710 USA
White, WD
;
Reves, J
论文数: 0引用数: 0
h-index: 0
机构:
Duke Univ, Med Ctr, Dept Anesthesiol, Div Cardiothorac Anesthesiol & Crit Care, Durham, NC 27710 USADuke Univ, Med Ctr, Dept Anesthesiol, Div Cardiothorac Anesthesiol & Crit Care, Durham, NC 27710 USA