Substrate specificity and screening of the integral membrane protease Pla

被引：13

作者：

Agarkov, Anton ^{[1
]}

Chauhan, Sadhana ^{[2
,3
]}

Lory, Pedro J. ^{[1
]}

Gilbertson, Scott R. ^{[1
]}

Motin, Vladimir L. ^{[2
,3
]}

机构：

[1] Univ Texas Galveston, Med Branch, Dept Pharmacol & Toxicol, Chem Biol Program, Galveston, TX 77555 USA

[2] Univ Texas Galveston, Med Branch, Dept Pathol, Galveston, TX 77555 USA

[3] Univ Texas Galveston, Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 01期

关键词：

D O I：

10.1016/j.bmcl.2007.09.104

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This paper reports a study to find small peptide substrates for the important virulence factor of Yersinia pestis, plasminogen activator, Pla. The method used to find small substrates for this protease is reported along with studies examining the ability of these peptides to inhibit activity of the enzyme. Through the use of parallel synthesis and positional scanning, small tripeptides were identified that are viable substrates for the protease. (c) 2007 Elsevier Ltd. All rights reserved.

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页码：427 / 431

页数：5

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