Adoptive cellular therapy: A race to the finish line

被引：307

作者：

June, Carl H. ^{[1
,2
]}

Riddell, Stanley R. ^{[3
]}

Schumacher, Ton N. ^{[4
]}

机构：

[1] Univ Penn, Perelman Sch Med, Ctr Cellular Immunotherapies, Philadelphia, PA 19104 USA

[2] Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[3] Univ Washington, Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA

[4] Netherlands Canc Inst, Div Immunol, NL-1066 CX Amsterdam, Netherlands

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2015年 / 7卷 / 280期

关键词：

CHIMERIC-ANTIGEN-RECEPTOR; TCR GENE-THERAPY; T-CELLS; IMMUNOTHERAPY TARGETS; ANTITUMOR-ACTIVITY; IMMUNE-RESPONSES; SAFETY; LYMPHOCYTES; TRANSGENE; TRANSPLANTATION;

D O I：

10.1126/scitranslmed.aaa3643

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Adoptive T cell transfer for cancer, chronic infection, and autoimmunity is an emerging field that shows promise in recent trials. Using the principles of synthetic biology, advances in cell culture and genetic engineering have made it possible to generate human T cells that display desired specificities and enhanced functionalities compared with the natural immune system. The prospects for widespread availability of engineered T cells have changed dramatically, given the recent entry of the pharmaceutical industry to this arena. Here, we discuss some of the challenges-such as regulatory, cost, and manufacturing-and opportunities, including personalized gene-modified T cells, that face the field of adoptive cellular therapy.

引用

页数：8

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