Apolipoprotein E gene ε2/ε3/ε4 polymorphism and myocardial infarction:: Case-control study in a large population sample

被引：9

作者：

Koch, Wemer ^{[1
,2
]}

Hoppmann, Petra ^{[1
,2
]}

Schoemig, Albeit ^{[1
,2
]}

Kastrati, Adrian ^{[1
,2
]}

机构：

[1] Tech Univ Munich, Deutsches Herzzentrum Munchen, Munich, Germany

[2] Tech Univ Munich, Klinikum Rechts Isar, D-8000 Munich, Germany

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2008年 / 125卷 / 01期

关键词：

apolipoprotein E; atherosclerosis; genetics; myocardial infarction;

D O I：

10.1016/j.ijcard.2007.01.012

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It has not been clearly established yet whether the epsilon 2/epsilon 3/epsilon 4 polymorphism of the gene encoding apolipoprotein E is associated with myocardial infarction. We addressed this issue in a large case-control sample and found no statistically significant relationship between the epsilon 2/epsilon 3/epsilon 4 polymorphism and myocardial infarction. The epsilon 2 allele and epsilon 2 epsilon 3 genotype showed trends towards lower risks of myocardial infarction than the epsilon 3 epsilon 3 genotype. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：116 / 117

页数：2

共 5 条

[1] Phenotype-dependent differences in apolipoprotein E metabolism and in cholesterol homeostasis in human monocyte-derived macrophages [J].