Intake of whole-grain products and risk of prostate cancer among men in the Danish Diet, Cancer and Health cohort study

被引：27

作者：

Egeberg, Rikke ^{[1
]}

Olsen, Anja ^{[1
]}

Christensen, Jane ^{[1
]}

Johnsen, Nina Fons ^{[1
]}

Loft, Steffen ^{[2
]}

Overvad, Kim ^{[3
]}

Tjonneland, Anne ^{[1
]}

机构：

[1] Danish Canc Soc, Inst Canc Epidemiol, DK-2100 Copenhagen, Denmark

[2] Univ Copenhagen, Inst Publ Hlth, Copenhagen, Denmark

[3] Aarhus Univ, Dept Epidemiol, Sch Publ Hlth, Aarhus, Denmark

来源：

CANCER CAUSES & CONTROL | 2011年 / 22卷 / 08期

关键词：

Whole-grain products; Prostate cancer; Prospective study; FOOD FREQUENCY QUESTIONNAIRE; COLORECTAL-CANCER; NUTRIENT INTAKE; DOSE-RESPONSE; RYE BRAN; CONSUMPTION; ANTIGEN; ADENOCARCINOMA; QUALITY; SOY;

D O I：

10.1007/s10552-011-9789-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

High intake of whole-grain products may protect against prostate cancer, but overall evidence is limited and inconclusive. The aim of the present study was to investigate the relationship between the intake of whole-grain products and risk of prostate cancer in a large prospective cohort. A total of 26,691 men aged 50-64 years participated in the Diet, Cancer and Health cohort study and provided information about diet and potential prostate cancer risk factors. During a median follow-up of 12.4 years, we identified 1,081 prostate cancer cases. Associations between whole-grain product intake and prostate cancer incidence were analyzed using Cox's regression model. Overall, there was no association between total intake of whole-grain products and prostate cancer risk (adjusted incidence rate ratio per 50 g day(-1): 1.00 (95% confidence interval: 0.96, 1.05)) as well as between intake of the specific whole-grain products: whole-grain rye bread, whole-grain bread, and oatmeal, and risk of prostate cancer. No risk estimates did differ according to either stage or grade of disease. Results from this prospective study suggest that higher intakes of total or specific whole-grain products are not associated with risk of prostate cancer in a population of Danish middle-aged men.

引用

页码：1133 / 1139

页数：7

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