Acidocalcisomes in Apicomplexan parasites

被引：34
作者：
Miranda, Kildare [1 ,2 ,3 ]
de Souza, Wanderley [3 ]
Plattner, Helmut [4 ]
Hentschel, Joachim [4 ]
Kawazoe, Urara [5 ]
Fang, Jianmin [1 ,2 ]
Moreno, Silvia N. J. [1 ,2 ]
机构：
[1] Univ Georgia, Ctr Trop & Emerging Global Dis, Athens, GA 30602 USA
[2] Univ Georgia, Paul D Coverdell Ctr 350, Dept Cellular Biol, Athens, GA 30602 USA
[3] UFRJ, CCS, IBCCF, Lab Ultraestrutura Celular Hertha Meyer, Rio De Janeiro, Brazil
[4] Univ Konstanz, Fachbereich Biol, D-78457 Constance, Germany
[5] Univ Estadual Campinas, IB, Dept Parasitol, Campinas, SP, Brazil
来源：
EXPERIMENTAL PARASITOLOGY | 2008年 / 118卷 / 01期
关键词：
D O I：
10.1016/j.exppara.2007.07.009
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Acidocalcisomes are acidic calcium stores found in diverse organisms, being conserved from bacteria to man. They posses an acidic matrix that contains several cations bound to phosphates, mainly present in the form of short and long polyphosphate chains. Their matrix is acidified through the action of proton pumps such as a vacuolar proton ATPase and a vacuolar proton pyrophosphatase. The calcium uptake occurs through a Ca2+/H+ counter transporting ATPase located in the membrane of the organelle. Acidocalcisomes have been identified in a variety of microorganisms, including Apicomplexan parasites such as Plasmodium and Eimeria species, and in Toxoplasina gondii. In this paper, we review the structural, biochemical and physiological aspects of acidocalcisomes in Apicomplexan parasites and discuss their functional roles in the maintenance of intracellular ion homeostasis.
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页码：2 / 9
页数：8
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