Posaconazole Promising but Problematic in Practice in Pediatric Patients

被引：13
作者：
Gwee, Amanda [1 ,2 ]
Cranswick, Noel [1 ,2 ,3 ]
Curtis, Nigel [1 ,2 ,3 ]
机构：
[1] Royal Childrens Hosp Melbourne, Infect Dis & Australian Paediat Pharmacol Res Uni, Parkville, Vic 3052, Australia
[2] Murdoch Childrens Res Inst, Parkville, Vic, Australia
[3] Univ Melbourne, Dept Paediat, Melbourne, Vic 3010, Australia
来源：
PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2015年 / 34卷 / 06期
关键词：
triazoles; antifungal agents; mycoses; child; pharmacokinetics; PHARMACOKINETICS; PROPHYLAXIS; ASPERGILLOSIS; INFECTIONS; EXPOSURE; THERAPY; SAFETY; BOY;
D O I：
10.1097/INF.0000000000000635
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Posaconazole is a broad-spectrum antifungal agent used for the prevention and treatment of invasive fungal infections. It is currently only licensed for use in children greater than 12 years of age. Absorption of the oral formulation is unpredictable and affected by mucositis and concomitant medications. We reviewed studies of posaconazole use in children younger than 12 years in relation to attainment of target serum concentrations.
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收藏
页码：604 / 606
页数：3
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