Advances of Microneedles in Biomedical Applications

被引：93
作者：
Xu, Jie [1 ,2 ]
Xu, Danfeng [3 ]
Xuan, Xuan [1 ]
He, Huacheng [2 ]
机构：
[1] Wenzhou Med Univ, Affiliated Hosp 1, Dept Dermatol, Wenzhou 325000, Peoples R China
[2] Wenzhou Med Univ, Sch Pharmaceut Sci, Key Lab Biotechnol & Pharmaceut Engn, Wenzhou 325035, Peoples R China
[3] Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Hangzhou Med Coll, Allergy Ctr,Dept Dermatol, Hangzhou 310014, Peoples R China
来源：
MOLECULES | 2021年 / 26卷 / 19期
关键词：
microneedle; classification; manufacture; biomedical application; pitfalls; SKIN-BARRIER FUNCTION; DRUG-DELIVERY; TRANSDERMAL DELIVERY; DISSOLVING MICRONEEDLES; COATED MICRONEEDLES; DRAWING LITHOGRAPHY; INSULIN; PATCHES; ARRAYS; NANOPARTICLES;
D O I：
10.3390/molecules26195912
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A microneedle (MN) is a painless and minimally invasive drug delivery device initially developed in 1976. As microneedle technology evolves, microneedles with different shapes (cone and pyramid) and forms (solid, drug-coated, hollow, dissolvable and hydrogel-based microneedles) have been developed. The main objective of this review is the applications of microneedles in biomedical areas. Firstly, the classifications and manufacturing of microneedle are briefly introduced so that we can learn the advantages and fabrications of different MNs. Secondly, research of microneedles in biomedical therapy such as drug delivery systems, diagnoses of disease, as well as wound repair and cancer therapy are overviewed. Finally, the safety and the vision of the future of MNs are discussed.
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页数：24
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