iPSC Technology: Platform for Drug Discovery

被引：23

作者：

Ellis, J. ^{[1
,2
,3
,4
]}

Bhatia, M. ^{[5
,6
]}

机构：

[1] Ontario Human iPS Cell Facil, Toronto, ON, Canada

[2] OCRiT, Toronto, ON, Canada

[3] Univ Toronto, Dept Mol Genet, Toronto, ON, Canada

[4] SickKids, Dev & Stem Cell Biol, Toronto, ON, Canada

[5] McMaster Univ, Fac Hlth Sci, Michael G Degroote Sch Med, McMaster Stem Cell & Canc Res Inst, Hamilton, ON, Canada

[6] McMaster Univ, OCRiT, Hamilton, ON, Canada

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2011年 / 89卷 / 05期

关键词：

PLURIPOTENT STEM-CELLS; PATIENT;

D O I：

10.1038/clpt.2011.22

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Disease-specific pluripotent stem cells are a source of affected cell types for drug discovery. The ability to reprogram somatic cells into induced pluripotent stem cells (iPSCs) provides a platform for generating cells from patients with different disease severities and drug metabolism responses. Although challenges remain for efficient differentiation and high-throughput scale-up, we propose that iPSCs have distinct advantages over embryonic stem cells (ESCs) for evaluating drugs by performing clinical trials on a dish.

引用

页码：639 / 641

页数：3

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