Micro Solid Phase Extraction Surface-Enhanced Raman Spectroscopy (μ-SPE/SERS) Screening Test for the Detection of the Synthetic Cannabinoid JWH-018 in Oral Fluid

被引：50
作者：
Deriu, Chiara [1 ]
Conticello, Irene [1 ,2 ]
Mebel, Alexander M. [1 ]
McCord, Bruce [1 ]
机构：
[1] Florida Int Univ, Dept Chem & Biochem, 11200 SW Eighth St, Miami, FL 33199 USA
[2] Univ Bologna, Sch Sci, Dept Chem Giacomo Ciamician, Via Selmi 2, I-40126 Bologna, BO, Italy
来源：
ANALYTICAL CHEMISTRY | 2019年 / 91卷 / 07期
关键词：
METAL NANOPARTICLES; RAPID DETECTION; SALIVA; SERS; ADSORPTION; MOLDEN; DRUGS; ABUSE;
D O I：
10.1021/acs.analchem.9b00335
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
An analytical protocol based on surface-enhanced Raman spectroscopy (SERS) and aimed at the detection of toxicologically relevant concentrations of JWH-018 in oral fluid is presented for the first time. A DFT-supported in-depth vibrational characterization of the drug in the solid state and in solution was also performed, providing a body of literature for future spectroscopic work on the compound. A Langmuir adsorption model was used to derive quantitative parameters such as the affinity of JWH-018 for citrate-capped gold nanospheres as well as the LOD. The application of the implemented method to the analysis of extracts from fortified oral fluid samples demonstrates the feasibility of SERS as an alternative to current immunoassays as a screening tool for use in emergency room settings.
引用
收藏
页码：4780 / 4789
页数：10
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