Clinical outcomes of lung metastasectomy in patients with colorectal cancer

被引:5
作者
Olmez, Omer Fatih [1 ]
Cubukcu, Erdem [1 ]
Bayram, Ahmet Sami [2 ]
Akcali, Unsal [3 ]
Evrensel, Turkkan [1 ]
Gebitekin, Cengiz [2 ]
机构
[1] Uludag Univ, Sch Med, Dept Med Oncol, TR-16059 Bursa, Turkey
[2] Uludag Univ, Sch Med, Dept Thorac Surg, TR-16059 Bursa, Turkey
[3] Uludag Univ, Sch Med, Dept Internal Med, TR-16059 Bursa, Turkey
关键词
Lung metastases; Colorectal cancer; Metastasectomy; Prognostic factors; Survival; PULMONARY METASTASES; SURGICAL RESECTION; PROGNOSTIC-FACTORS; CARCINOMA; SURVIVAL; SURGERY;
D O I
10.3748/wjg.v18.i7.662
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
AIM: To investigate prognostic factors of survival following curative, non-palliative surgical removal of lung metastases secondary to colorectal cancer (CRC). METHODS: Between 1999 and 2009, a radical metastasectomy with curative intent was performed on lung metastases in 21 patients with CRC (15 male and 6 female; mean age: 57.4 +/- 11.8 years; age range: 29-74 years) who had already undergone primary tumour resection. RESULTS: The mean number of lung metastases ranged from one to five. The mean overall survival was 71 +/- 35 mo (median: 25 mo). After adjusting for potential confounders, multivariable Cox regression analyses predicted only the number of lung metastases (1 vs >= 2; hazard ratio: 7.60, 95% confidence interval: 1.18-17.2, P = 0.03) as an independent predictor of poor survival following lung resection for metastatic CRC. CONCLUSION: Resection of lung metastases is a safe and effective treatment in selected CRC patients with single lung metastases. (C) 2012 Baishideng. All rights reserved.
引用
收藏
页码:662 / 665
页数:4
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