The effects of olibanum administered to methimazole-treated dams during lactation on learning and memory of offspring rats

被引：21

作者：

Hosseini, Mahmoud ^{[1
,2
]}

Shafei, Mohammad Naser ^{[1
,3
]}

Safari, Vajiheh ^{[1
]}

Taiarani, Zahra ^{[1
]}

Ladani, Marzieh Kafami ^{[1
]}

Sadeghian, Reihaneh ^{[4
]}

机构：

[1] Univ Med Sci MUMS, Neurosci Res Ctr, Mashhad, Iran

[2] Univ Med Sci MUMS, Sch Med, Dept Physiol, Mashhad, Iran

[3] Univ Med Sci MUMS, Pharmacol Res Ctr Med Plants, Mashhad, Iran

[4] Ferdowsi Univ Mashhad, Fac Sci, Dept Biol, Mashhad, Iran

来源：

NATURAL PRODUCT RESEARCH | 2012年 / 26卷 / 16期

关键词：

hypothyroidism; learning; memory; olibanum; offspring; lactation; rat; THYROID-HORMONE ACTION; BOSWELLIA-SERRATA; DENTATE GYRUS; SYNAPTIC-TRANSMISSION; ADULT HIPPOCAMPUS; GUM RESIN; HYPOTHYROIDISM; PLASTICITY; BRAIN; IMPAIRMENT;

D O I：

10.1080/14786419.2011.566223

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The effect of olibanum administered during lactation to methimazole-treated dams on the learning of offspring was evaluated. The animals were treated for 60 days from the first day of lactation period: group 1 - tap water, group 2-0.03% methimazole and groups 3 and 4-0.03% methimazole with 0.25% or 0.125% olibanum, respectively. The serum thyroxin level in the offspring of group 2 was significantly lower than that of group 1. However, there was no difference compared to groups 3 and 4. In a Morris water maze, the distance and time latency to reach the platform in offspring of group 2 was significantly higher than groups 1, 3 and 4. In probe trial, the time spent in target quadrant (Q(1)) by offspring of group 2 was lower than groups 1, 3 and 4. It is suggested that impaired learning and memory in the offspring of hypothyroid rats may be prevented by olibanum.

引用

页码：1544 / 1548

页数：5

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