Pathobiology of CD30+ cutaneous T-cell lymphomas

被引:36
作者
Kadin, ME
机构
[1] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA
[2] Harvard Univ, Sch Med, Boston, MA 02215 USA
关键词
D O I
10.1111/j.0303-6987.2006.00507.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
CD30+ cutaneous lymphoproliferative disorders include lymphomatoid papulosis (LyP) and anaplastic large cell lymphoma (ALCL). LyP is associated with development of lymphoma in nearly 20% of patients. Herein is reviewed the clonal relationship of LyP to malignant lymphoma, the concept of a common stem cell for LyP and associated lymphomas, and the role of genetic instability in lymphomagenesis. The possible role of the CD30+ cell as a regulatory T-cell is introduced and a model for progression of LyP to ALCL is illustrated.
引用
收藏
页码:10 / 17
页数:8
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