The Congenital Heart Disease Brain: Prenatal Considerations for Perioperative Neurocritical Care

被引:8
作者
Ortinau, Cynthia M. [1 ]
Shimony, Joshua S. [2 ]
机构
[1] Washington Univ, Dept Pediat, St Louis, MO 63110 USA
[2] Washington Univ, Mallinkrodt Inst Radiol, St Louis, MO 63110 USA
基金
美国国家卫生研究院;
关键词
Congenital heart disease; Brain; Brain development; Brain injury; Fetal; Prenatal; WHITE-MATTER INJURY; AMPLITUDE-INTEGRATED ELECTROENCEPHALOGRAPHY; LATE OLIGODENDROCYTE PROGENITORS; CEREBRAL-BLOOD-FLOW; CARDIAC-SURGERY; NEURODEVELOPMENTAL OUTCOMES; VASCULAR MALPERFUSION; PRETERM BIRTH; FETAL-GROWTH; FETUSES;
D O I
10.1016/j.pediatrneurol.2020.01.002
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Altered brain development has been highlighted as an important contributor to adverse neurodevelopmental outcomes in children with congenital heart disease. Abnormalities begin prenatally and include micro- and macrostructural disturbances that lead to an altered trajectory of brain growth throughout gestation. Recent progress in fetal imaging has improved understanding of the neurobiological mechanisms and risk factors for impaired fetal brain development. The impact of the prenatal environment on postnatal neurological care has also gained increased focus. This review summarizes current data on the timing and pattern of altered prenatal brain development in congenital heart disease, the potential mechanisms of these abnormalities, and the association with perioperative neurological complications. (C) 2020 Elsevier Inc. All rights reserved.
引用
收藏
页码:23 / 30
页数:8
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