Renal Cell Carcinoma as a Metabolic Disease: An Update on Main Pathways, Potential Biomarkers, and Therapeutic Targets

被引：119

作者：

di Meo, Nicola Antonio ^{[1
]}

Lasorsa, Francesco ^{[1
]}

Rutigliano, Monica ^{[1
]}

Loizzo, Davide ^{[1
]}

Ferro, Matteo ^{[2
]}

Stella, Alessandro ^{[3
]}

Bizzoca, Cinzia ^{[4
]}

Vincenti, Leonardo ^{[4
]}

Pandolfo, Savio Domenico ^{[5
]}

Autorino, Riccardo ^{[5
]}

Crocetto, Felice ^{[6
]}

Montanari, Emanuele ^{[7
]}

Spilotros, Marco ^{[1
]}

Battaglia, Michele ^{[1
]}

Ditonno, Pasquale ^{[1
]}

Lucarelli, Giuseppe ^{[1
]}

机构：

[1] Univ Bari Aldo Moro, Dept Emergency & Organ Transplantat, Urol Androl & Kidney Transplantat Unit, I-70124 Bari, Italy

[2] IRCCS, Div Urol, European Inst Oncol, I-20141 Milan, Italy

[3] Univ Bari Aldo Moro, Dept Biomed Sci & Human Oncol, Lab Human Genet, I-70124 Bari, Italy

[4] Polyclin Hosp, Div Gen Surg, I-70124 Bari, Italy

[5] VCU Hlth, Div Urol, Richmond, VA 23298 USA

[6] Univ Naples Federico II, Dept Neurosci Reprod Sci & Odontostomatol, I-80131 Naples, Italy

[7] Univ Milan, Dept Clin Sci & Community Hlth, I-20122 Milan, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 22期

关键词：

renal cell carcinoma; metabolomics; metabolism; Warburg effect; biomarker; NF-KAPPA-B; 1ST-LINE TREATMENT; CHOLESTEROL-METABOLISM; MESENCHYMAL TRANSITION; GLUCOSE TRANSPORTERS; ANDROGEN RECEPTOR; TUMOR PROGRESSION; LIPID STORAGE; CANCER-CELLS; EXPRESSION;

D O I：

10.3390/ijms232214360

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Clear cell renal cell carcinoma (ccRCC) is the most frequent histological kidney cancer subtype. Over the last decade, significant progress has been made in identifying the genetic and metabolic alterations driving ccRCC development. In particular, an integrated approach using transcriptomics, metabolomics, and lipidomics has led to a better understanding of ccRCC as a metabolic disease. The metabolic profiling of this cancer could help define and predict its behavior in terms of aggressiveness, prognosis, and therapeutic responsiveness, and would be an innovative strategy for choosing the optimal therapy for a specific patient. This review article describes the current state-of-the-art in research on ccRCC metabolic pathways and potential therapeutic applications. In addition, the clinical implication of pharmacometabolomic intervention is analyzed, which represents a new field for novel stage-related and patient-tailored strategies according to the specific susceptibility to new classes of drugs.

引用

页数：28

共 223 条

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