Accuracy of Combined Computed Tomography Colonography and Dual Energy Iiodine Map Imaging for Detecting Colorectal masses using High-pitch Dual-source CT

被引:23
作者
Sun, Kai [1 ,2 ,3 ]
Han, Ruijuan [4 ]
Han, Yang [1 ]
Shi, Xuesen [5 ]
Hu, Jiang [6 ]
Lu, Bin [2 ,3 ]
机构
[1] Baotou Cent Hosp, Dept Radiol, Baotou 014040, Peoples R China
[2] Chinese Acad Med Sci, State Key Lab Cardiovasc Dis, Natl Ctr Cardiovasc Dis, Dept Radiol,Fu Wai Hosp, Beijing 100037, Peoples R China
[3] Peking Union Med Coll, Beijing 100037, Peoples R China
[4] Capital Med Univ, Chaoyang Hosp, Dept Cardiol, Beijing 100020, Peoples R China
[5] Baotou Cent Hosp, Dept Gastroenterol, Baotou 014040, Peoples R China
[6] Baotou Cent Hosp, Dept Surg, Baotou 014040, Peoples R China
来源
SCIENTIFIC REPORTS | 2018年 / 8卷
关键词
CANCER; COLONOSCOPY; TIME;
D O I
10.1038/s41598-018-22188-x
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
To evaluate the diagnostic accuracy of combined computed tomography colonography (CTC) and dual-energy iodine map imaging for detecting colorectal masses using high-pitch dual-source CT, compared with optical colonography (OC) and histopathologic findings. Twenty-eight consecutive patients were prospectively enrolled in this study. All patients were underwent contrast-enhanced CTC acquisition using dual-energy mode and OC and pathologic examination. The size of the space-occupied mass, the CT value after contrast enhancement, and the iodine value were measured and statistically compared. The sensitivity, specificity, accuracy rate, and positive predictive and negative predictive values of dual-energy contrast-enhanced CTC were calculated and compared between conventional CTC and dual-energy iodine images. The iodine value of stool was significantly lower than the colonic neoplasia (P < 0.01). The sensitivity of conventional CTC was 95.6% (95% CI = 77.9%-99.2%), combined CTC and dual-energy iodine maps imaging was 95.6% (95% CI = 77.9%-99.2%). The specificity of the two methods was 42.8% (95% CI = 15.4%-93.5%) and 100% (95% CI = 47.9%-100%; P = 0.02), respectively. Compared with optical colonography and histopathology, combined CTC and dual-energy iodine maps imaging can distinguish stool and colonic neoplasia, distinguish between benign and malignant tumors initially and improve the diagnostic accuracy of CTC for colorectal cancer screening.
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页数:7
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