One pot synthesis of α-ketoamides from ethylarenes and amines: a metal free difunctionalization strategy

被引：17
作者：
Ramanathan, Mani [1 ]
Kuo, Chun-Kai [1 ]
Liu, Shiuh-Tzung [1 ]
机构：
[1] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 48期
关键词：
OXIDATIVE AMIDATION; ROOM-TEMPERATURE; METHYL KETONES; INHIBITORS; ACETOPHENONES; CATALYST; CARBONYLATION; AMINATION; ALKYNES; IODINE;
D O I：
10.1039/c6ob02361d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
One-pot and metal free synthesis of alpha-ketoamides has been described through in situ generation of aryl ketones from easily available ethylarenes followed by amidation with various amines. This multiple oxidation protocol involves catalytic I-2-pyridine-TBHP (t-butyl hydroperoxide) mediated oxidative benzylic carbonylation and sequential NaI-TBHP mediated oxidative amidation without using any solvent.
引用
收藏
页码：11446 / 11453
页数：8
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