Spectral and lifetime domain measurements of rat brain tumours

被引：0

作者：

Abi, Haidar D. ^{[1
,2
]}

Leh, B. ^{[1
]}

Allaoua, K. ^{[1
]}

Genoux, A. ^{[1
]}

Siebert, R. ^{[1
]}

Steffenhagen, M. ^{[3
]}

Peyrot, D. ^{[3
]}

Sandeau, N. ^{[3
]}

Vever-Bizet, C. ^{[3
]}

Bourg-Heckly, G. ^{[3
]}

Chebbi, I. ^{[4
]}

Collado-Hilly, M. ^{[5
]}

机构：

[1] Lab IMNC, UMR 8165, F-91405 Orsay, France

[2] Univ Paris 07, F-75012 Paris, France

[3] UPMC Univ Paris 06, FRE 3207, ANBioPhy, F-75005 Paris, France

[4] UPMC, SARL Nanobacterie, Chez ANBIOPhy, CNRS,FRE 3207, Paris, France

[5] INSERM, U757, F-91405 Orsay, France

来源：

PHOTONIC THERAPEUTICS AND DIAGNOSTICS VIII, PTS 1 AND 2 | 2012年 / 8207卷

关键词：

intrinsic fluorescence; autofluorescence probe; fluorescence spectroscopy; nonlinear excitation; fluorescence lifetime spectroscopy; glioblastoma; redox ratio; OPTICAL SPECTROSCOPY; RESECTION; GLIOMA;

D O I：

10.1117/12.907411

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

During glioblastoma surgery, delineation of the brain tumour margins remains difficult especially since infiltrated and normal tissues have the same visual appearance. This problematic constitutes our research interest. We developed a fibre-optical fluorescence probe for spectroscopic and time domain measurements. First measurements of endogenous tissue fluorescence were performed on fresh and fixed rat tumour brain slices. Spectral characteristics, fluorescence redox ratios and fluorescence lifetime measurements were analysed. Fluorescence information collected from both, lifetime and spectroscopic experiments, appeared promising for tumour tissue discrimination. Two photon measurements were performed on the same fixed tissue. Different wavelengths are used to acquire two-photon excitation-fluorescence of tumorous and healthy sites.

引用

页数：11

共 28 条

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