DEVELOPMENT AND VALIDATION OF AN HPLC-UV METHOD FOR DETERMINATION OF SYNTHETIC FOOD COLORANTS

被引:0
|
作者
Vlase, Laurian [1 ]
Muntean, Dana [1 ]
Cobzac, Simona Codruta [2 ]
Filip, Lorena [1 ]
机构
[1] Iuliu Hatieganu Univ Med & Pharm, Fac Pharm, RO-400023 Cluj Napoca, Romania
[2] Univ Babes Bolyai, Fac Chem & Chem Engn, RO-400028 Cluj Napoca, Romania
关键词
synthetic food colorants; liquid chromatography; method validation; PERFORMANCE LIQUID-CHROMATOGRAPHY; DYES; ARRAY; TARTRAZINE; SEPARATION; DRINKS;
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Liquid chromatography with UV detection has been used to develop a determination method for nine water-soluble synthetic colorants (E102, E123, E124, E110, E122, E104, E133, E127, E131). The colors were separated in 8 minutes on a C18 analytical column, using a mobile phase mixture of 100 mM ammonium acetate/acetonitrile gradient elution. The analytical characteristics of the separation were evaluated. Good linearity (R-2=0.9982-0.9997) and adequate limits of quantification were achieved.
引用
收藏
页码:719 / 725
页数:7
相关论文
共 50 条
  • [21] HPLC-UV Method Development and Validation to Monitor Difluprednate Synthesis
    Bartolo, Nicolette Sammut
    Szijj, Janis Vella
    Ferrito, Victor
    Serracino-Inglott, Anthony
    JOURNAL OF CHROMATOGRAPHIC SCIENCE, 2023, 61 (04) : 322 - 328
  • [22] Determination of parthenin in Parthenium hysterophorus L. by means of HPLC-UV: Method development and validation
    Saucedo Hernandez, Y.
    Bravo Sanchez, L.
    Gonzalez Bedia, M.
    Torres Gomez, L.
    Jorge Rodriguez, E.
    Gonzalez San Miguel, H.
    Gonzalez Mosquera, D.
    Polin Garcia, L.
    Dhooghe, L.
    Theunis, M.
    Pieters, L.
    Apers, S.
    PLANTA MEDICA, 2011, 77 (12) : 1274 - 1275
  • [23] Development and Validation of a Simple HPLC-UV Assay Method for Determination of Levetiracetam Concentrations in Human Plasma
    Kharouba, Maged
    Mahmoud, Sherif Hanafy
    ANALYTICA, 2023, 4 (01): : 1 - 9
  • [24] Development and Validation of an HPLC-UV Method for Determination of Sertraline Hydrochloride and Application to Study Dissolution of Tablets
    Al-Nimry, Suhair S.
    Jaber, Malak A.
    LATIN AMERICAN JOURNAL OF PHARMACY, 2017, 36 (04): : 665 - 672
  • [25] Determination of parthenin in Parthenium hysterophorus Linn (feverfew) by means of HPLC-UV: method development and validation
    Saucedo Hernandez, Y.
    Bravo Sanchez, L.
    Gonzalez Bedia, M. M.
    Torres Gomez, L.
    Jorge Rodriguez, E.
    Gonzalez San Miguel, H. M.
    Gonzalez Mosquera, D.
    Theunis, M.
    Pieters, L.
    Apers, S.
    PLANTA MEDICA, 2009, 75 (09) : 1005 - 1005
  • [26] DEVELOPMENT AND VALIDATION OF HPLC-UV METHOD FOR THE DETERMINATION OF CLOPIDOGREL IN PHARMACEUTICAL DOSAGE FORM AND HUMAN PLASMA
    Javed, Muhammad. K.
    Iqbal, Zafar
    Khan, Abbas
    Khan, Abad
    Shah, Yasar
    Ahmad, Lateef
    JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 2011, 34 (18) : 2118 - 2129
  • [27] Determination of parthenin in Parthenium hysterophorus L. by means of HPLC-UV: Method development and validation
    Saucedo Hernandez, Yanelis
    Bravo Sanchez, Luis
    Gonzalez Bedia, Mirtha Mayra
    Torres Gomez, Luis
    Jorge Rodriguez, Elisa
    San Miguel, Hilda M. Gonzalez
    Gonzalez Mosquera, Dulce
    Polin Garcia, Livier
    Dhooghe, Liene
    Theunis, Mart
    Pieters, Luc
    Apers, Sandra
    PHYTOCHEMISTRY LETTERS, 2011, 4 (02) : 134 - 137
  • [28] DEVELOPMENT AND VALIDATION OF A HPLC-UV METHOD FOR SIMULTANEOUS DETERMINATION OF CEFTRIAXONE AND SULBACTAM IN POWDER FOR INJECTION FORMULATION
    Kundu, Sarbojit
    Majumder, Tapas
    Barat, Prasanta Kumar
    Ray, Subrata Kumar
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2014, 5 (10): : 4529 - 4534
  • [29] Development and validation of an HPLC-UV method for the determination of insulin in rat plasma: Application to pharmacokinetic study
    Ravi, Sheshala
    Peh, Kok Khiang
    Darwis, Yusrida
    Murthy, Bhavanasi Krishna
    Singh, Thakur Raghu Rai
    CHROMATOGRAPHIA, 2007, 66 (9-10) : 805 - 809
  • [30] Development and Validation of HPLC-UV Method for the Determination of Diclofenac in Human Plasma with Application to a Pharmacokinetic Study
    Arisoy, Gulsum Gul
    Dural, Emrah
    Mergen, Gorkem
    Arisoy, Mustafa
    Guvendik, Gulin
    Soylemezoglu, Tulin
    TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, 2016, 13 (03) : 292 - 299