Safety of Monoclonal Antibodies in Children Affected by SARS-CoV-2 Infection

被引:14
作者
Romani, Lorenza [1 ]
Carducci, Francesca Ippolita Calo [1 ]
Chiurchiu, Sara [1 ]
Cursi, Laura [1 ]
De Luca, Maia [1 ]
Di Giuseppe, Martina [1 ]
Krzysztofiak, Andrzej [1 ]
Lancella, Laura [1 ]
Palma, Paolo [2 ,3 ]
Vallesi, Leonardo [4 ]
Corsetti, Tiziana [4 ]
Campana, Andrea [5 ]
Nicastri, Emanuele [6 ]
Rossi, Paolo [3 ,7 ]
Bernardi, Stefania [1 ]
机构
[1] Bambino Gesu Pediat Hosp, Immunol & Infect Dis Unit, IRCCS, I-00165 Rome, Italy
[2] Bambino Gesu Pediat Hosp, Res Unit Congenital & Perinatal Infect, IRCCS, I-00165 Rome, Italy
[3] Univ Roma Tor Vergata, Dept Syst Med, Chair Pediat, I-00133 Rome, Italy
[4] Bambino Gesu Pediat Hosp, Hosp Pharm Unit, IRCCS, I-00165 Rome, Italy
[5] Bambino Gesu Pediat Hosp, Dept Pediat, IRCCS, I-00165 Rome, Italy
[6] IRCCS, Natl Inst Infect Dis, I-00149 Rome, Italy
[7] Bambino Gesu Pediat Hosp, Acad Dept Pediat, IRCCS, I-00165 Rome, Italy
来源
CHILDREN-BASEL | 2022年 / 9卷 / 03期
关键词
COVID-19; monoclonal antibody; children;
D O I
10.3390/children9030369
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Monoclonal antibody therapies for COVID-19 have been frequently used in adults, whereas there are little data regarding the safety or efficacy of monoclonal antibody treatments in pediatric patients affected by COVID-19. We report our experience in the administration of mAb as a treatment for SARS-CoV-2 infection in children aged from 24 days to 18 years old.
引用
收藏
页数:6
相关论文
共 26 条
[21]  
WHO, 2010, WORLD MALARIA REPORT 2010, P1
[22]   COVID-19 mental health impact among children with early brain injury and associated conditions [J].
Williams, Tricia S. ;
Deotto, Angela ;
Roberts, Samantha D. ;
Ford, Meghan K. ;
Desire, Naddley ;
Cunningham, Sarah .
CHILD NEUROPSYCHOLOGY, 2022, 28 (05) :627-648
[23]   Initial Guidance on Use of Monoclonal Antibody Therapy for Treatment of Coronavirus Disease 2019 in Children and Adolescents [J].
Wolf, Joshua ;
Abzug, Mark J. ;
Wattier, Rachel L. ;
Sue, Paul K. ;
Vora, Surabhi B. ;
Zachariah, Philip ;
Dulek, Daniel E. ;
Waghmare, Alpana ;
Olivero, Rosemary ;
Downes, Kevin J. ;
James, Scott H. ;
Pinninti, Swetha G. ;
Yarbrough, April ;
Aldrich, Margaret L. ;
MacBrayne, Christine E. ;
Soma, Vijaya L. ;
Grapentine, Steven P. ;
Oliveira, Carlos R. ;
Hayes, Molly ;
Kimberlin, David W. ;
Jones, Sarah B. ;
Bio, Laura L. ;
Morton, Theodore H. ;
Hankins, Jane S. ;
Maron, Gabriela M. ;
Timberlake, Kathryn ;
Young, Jennifer L. ;
Orscheln, Rachel C. ;
Schwenk, Hayden T. ;
Goldman, David L. ;
Groves, Helen E. ;
Huskins, W. Charles ;
Rajapakse, Nipunie S. ;
Lamb, Gabriella S. ;
Tribble, Alison C. ;
Lloyd, Elizabeth C. ;
Hersh, Adam L. ;
Thorell, Emily A. ;
Ratner, Adam J. ;
Chiotos, Kathleen ;
Nakamura, Mari M. .
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY, 2021, 10 (05) :629-634
[24]   Epidemiology, Clinical Features, and Disease Severity in Patients With Coronavirus Disease 2019 (COVID-19) in a Children's Hospital in New York City, New York [J].
Zachariah, Philip ;
Johnson, Candace L. ;
Halabi, Katia C. ;
Ahn, Danielle ;
Sen, Anita, I ;
Fischer, Avital ;
Banker, Sumeet L. ;
Giordano, Mirna ;
Manice, Christina S. ;
Diamond, Rebekah ;
Sewell, Taylor B. ;
Schweickert, Adam J. ;
Babineau, John R. ;
Carter, R. Colin ;
Fenster, Daniel B. ;
Orange, Jordan S. ;
McCann, Teresa A. ;
Kernie, Steven G. ;
Saiman, Lisa .
JAMA PEDIATRICS, 2020, 174 (10)
[25]  
Zhu N, 2020, NEW ENGL J MED, V382, P727, DOI [10.1056/NEJMoa2001017, 10.1172/JCI89857]
[26]   Why is COVID-19 less severe in children? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections [J].
Zimmermann, Petra ;
Curtis, Nigel .
ARCHIVES OF DISEASE IN CHILDHOOD, 2021, 106 (05) :429-439