Two new polycyclic polyprenylated acylphloroglucinols from Hypericum curvisepalum N. Robson

被引：2
|
作者：
Zhou, Zhong-Bo [1 ,2 ,4 ]
Shi, Wen-Pan [2 ]
Zeng, Hong [1 ]
Huang, You-Yi [1 ]
Wei, Xian [1 ]
Pan, Ke [3 ]
Teng, Li-Ping [1 ]
机构：
[1] Youjiang Med Univ Nationalities, Sch Pharm, 98 Chengxiang Rd, Baise 533000, Peoples R China
[2] Tarim Univ, Xinjiang Prod & Construct Corps, Key Lab Protect & Utilizat Biol Resources Tarim B, Alaer 843300, Peoples R China
[3] China Pharmaceut Univ, Sch Tradit Chinese Pharm, State Key Lab Nat Med, 639 Longmian Rd, Nanjing 211198, Peoples R China
[4] Guangxi Database Construct & Applicat Engn Res Ct, 98 Chengxiang Rd, Baise 533000, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2022年 / 48卷
关键词：
Polycyclic polyprenylated acylphloroglucinols; Hypericum curvisepalum; Antibacterial activity; Cytotoxic activity; DERIVATIVES; GENUS;
D O I：
10.1016/j.phytol.2022.01.015
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Phytochemical investigation of the whole plant of Hypericum curvisepalum led to the isolation of nine polycyclic polyprenylated acylphloroglucinols (1-9). Among them, curvisepalumiones A (1) and B (2) are two new compounds and their structures were elucidated based on extensive spectroscopic data analysis combined with Rh-2(OCOCF3)(4)-induced electronic circular dichroism experiment. Cytotoxic assay showed that all the tested compounds except for 1 was moderately cytotoxic against human hepatocarcinoma cell line SMMC-7721 cell line, while compounds 3 and 4 also exhibited cytotoxicity toward MGC-803 cells. In addition, compound 2 exhibited weak inhibitory activity against Bacillus subtilis.
引用
收藏
页码：43 / 46
页数：4
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