Two new polycyclic polyprenylated acylphloroglucinols from Hypericum curvisepalum N. Robson

被引：2
|
作者：
Zhou, Zhong-Bo [1 ,2 ,4 ]
Shi, Wen-Pan [2 ]
Zeng, Hong [1 ]
Huang, You-Yi [1 ]
Wei, Xian [1 ]
Pan, Ke [3 ]
Teng, Li-Ping [1 ]
机构：
[1] Youjiang Med Univ Nationalities, Sch Pharm, 98 Chengxiang Rd, Baise 533000, Peoples R China
[2] Tarim Univ, Xinjiang Prod & Construct Corps, Key Lab Protect & Utilizat Biol Resources Tarim B, Alaer 843300, Peoples R China
[3] China Pharmaceut Univ, Sch Tradit Chinese Pharm, State Key Lab Nat Med, 639 Longmian Rd, Nanjing 211198, Peoples R China
[4] Guangxi Database Construct & Applicat Engn Res Ct, 98 Chengxiang Rd, Baise 533000, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2022年 / 48卷
关键词：
Polycyclic polyprenylated acylphloroglucinols; Hypericum curvisepalum; Antibacterial activity; Cytotoxic activity; DERIVATIVES; GENUS;
D O I：
10.1016/j.phytol.2022.01.015
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Phytochemical investigation of the whole plant of Hypericum curvisepalum led to the isolation of nine polycyclic polyprenylated acylphloroglucinols (1-9). Among them, curvisepalumiones A (1) and B (2) are two new compounds and their structures were elucidated based on extensive spectroscopic data analysis combined with Rh-2(OCOCF3)(4)-induced electronic circular dichroism experiment. Cytotoxic assay showed that all the tested compounds except for 1 was moderately cytotoxic against human hepatocarcinoma cell line SMMC-7721 cell line, while compounds 3 and 4 also exhibited cytotoxicity toward MGC-803 cells. In addition, compound 2 exhibited weak inhibitory activity against Bacillus subtilis.
引用
收藏
页码：43 / 46
页数：4
相关论文
共 50 条
  • [21] Polyprenylated acylphloroglucinols from the fruits of Hypericum henryi
    Liao, Yang
    Yang, Shu-Ya
    Li, Xiao-Nian
    Yang, Xing-Wei
    Xu, Gang
    SCIENCE CHINA-CHEMISTRY, 2016, 59 (09) : 1216 - 1223
  • [22] Polycyclic polyprenylated acylphloroglucinols from Hypericum sampsonii Hance and their anti-inflammatory activity
    Li, Yanzhen
    Wang, Mingqiang
    Su, Jianhui
    Wang, Yuanyuan
    Zhao, Zhongxiang
    Sun, Zhanghua
    FITOTERAPIA, 2023, 169
  • [23] seco-Polycyclic polyprenylated acylphloroglucinols with unusual carbon skeletons from Hypericum ascyron
    Kong, Ling-Mei
    Long, Xian-Wen
    Yang, Xing-Wei
    Xia, Fan
    Khan, Afsar
    Yan, Hui
    Deng, Jun
    Li, Xian
    Xu, Gang
    TETRAHEDRON LETTERS, 2017, 58 (22) : 2113 - 2117
  • [24] Diverse polycyclic polyprenylated acylphloroglucinols with anti-neuroinflammatory activity from Hypericum beanii
    Li, Ya-Wei
    Lu, Wei-Jia
    Zhou, Xin
    Zhang, Chao
    Li, Xue-Yan
    Tang, Peng-Fei
    Kong, Ling-Yi
    Xu, Wen-Jun
    BIOORGANIC CHEMISTRY, 2022, 127
  • [25] Hyperpatulones A-F, polycyclic polyprenylated acylphloroglucinols from Hypericum patulum and their cytotoxic activities
    Wu, Zhong-Nan
    Niu, Qian-Wen
    Zhang, Yu-Bo
    Luo, Ding
    Li, Qing-Guo
    Li, Ying-Ying
    Kuang, Guang-Kai
    He, Li-Jun
    Wang, Guo-Cai
    Li, Yao-Lan
    RSC ADVANCES, 2019, 9 (14): : 7961 - 7966
  • [26] Discovery of bioactive polycyclic polyprenylated acylphloroglucinols with adamantine/homoadamantane skeletons from Hypericum wilsonii
    Tao, Bo
    Li, Yongqi
    Shi, Zhengyi
    Duan, Yulin
    Guo, Yi
    Huang, Xinye
    Li, Jie
    Zhang, Yeting
    Chen, Ming
    Song, Fei
    Lan, Xueqi
    Sun, Weiguang
    Gu, Lianghu
    Qi, Changxing
    Zhang, Yonghui
    PHYTOCHEMISTRY, 2024, 218
  • [27] Hyperbenzones A and B, two 1,2-seco and rearranged polycyclic polyprenylated acylphloroglucinols from Hypericum beanii
    Lu, Weijia
    Zhang, Yanqiu
    Li, Yawei
    Ye, Shengtao
    Luo, Jun
    Kong, Lingyi
    Xu, Wenjun
    CHINESE CHEMICAL LETTERS, 2022, 33 (08) : 4121 - 4125
  • [28] Polycyclic Polyprenylated Acylphloroglucinols and Chromone O-Glucosides from Hypericum henryi subsp uraloides
    Chen, Xuan-Qin
    Li, Yan
    Cheng, Xiao
    Wang, Kou
    He, Juan
    Pan, Zheng-Hong
    Li, Ming-Ming
    Peng, Li-Yan
    Xu, Gang
    Zhao, Qin-Shi
    CHEMISTRY & BIODIVERSITY, 2010, 7 (01) : 196 - 204
  • [29] Two new seco-polycyclic polyprenylated acylphloroglucinol from Hypericum sampsonii
    Zhang, Zi-Zhen
    Zeng, Yan-Rong
    Li, Ya-Nan
    Hu, Zhan-Xing
    Huang, Lie-Jun
    Gu, Wei
    Hao, Xiao-Jiang
    Yuan, Chun-Mao
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2021, 19 (01) : 216 - 219
  • [30] Kiiacylphnols A-H, eight undescribed polycyclic polyprenylated acylphloroglucinols with anticancer activities from Hypericum przewalskii Maxim
    Duan, Yulin
    Hu, Ping
    Guo, Yi
    Bu, Pengfei
    Shi, Zhengyi
    Cao, Yunfang
    Zhang, Yeting
    Hu, Hong
    Tong, Qingyi
    Qi, Changxing
    Zhang, Yonghui
    PHYTOCHEMISTRY, 2022, 199
12345