Mitoxantrone polybutyl cyanoacrylate nanoparticles as an anti-neoplastic targeting drug delivery system

Mitoxantrone polybutyl cyanoacrylate nanoparticles (PBCA-NP) for use as an anti-neoplastic targeting drug delivery system were prepared by the emulsion polymerization method, Their surface charge, drug loading, stability, morphology, size, release characteristics in vitro and distribution in animals were studied. The results revealed that their mean diameter was 55.11 mm, their drug load was 46.77% and their embedding ratio was 84.12%; their surface is negatively charged and their release characteristics in vitro obey two-phase kinetic laws. A colloidal solution of mitoxantrone PBCA-NP was sterilized by boiling for 30 min. After i.v. injection of H-3-mitoxantrone PBCA-NP, the radioactivity was mainly concentrated in the liver, and the radioactivity in liver tumors was higher than in liver tissue. Fifteen minutes after the i.v. injection, mitoxantrone PBCA-NP were observed in the parenchymal cells. This method of preparation helps to increase the anti-liver-tumor efficacy and decrease the toxicity of mitoxantrone.