Genetic polymorphism of serotonin transporter 5-HTTLPR: involvement in smoking behaviour

被引：16

作者：

Ehara Watanabe, Maria Angelica ^{[1
]}

Vargas Nunes, Sandra Odebrechet ^{[2
]}

Amarante, Marla Karine ^{[1
]}

Guembarovski, Roberta Losi ^{[1
]}

Maeda Oda, Julie Massayo ^{[1
]}

Alves De Lima, Kalil William ^{[1
]}

Pelegrinelli Fungaro, Maria Helena ^{[1
]}

机构：

[1] Univ Estadual Londrina, Dept Pathol Sci, Mol Genet Lab, Univ Hosp, BR-86051990 Londrina, Brazil

[2] Univ Estadual Londrina, Dept Psychiat, Univ Hosp, BR-86051990 Londrina, Brazil

来源：

JOURNAL OF GENETICS | 2011年 / 90卷 / 01期

关键词：

serotonin; smoking; 5-HTT; genetic polymorphism; NICOTINE REPLACEMENT THERAPY; PROMOTER POLYMORPHISM; CIGARETTE-SMOKING; FOOD-INTAKE; ASSOCIATION; ALCOHOL; BINDING; REGION; SUSCEPTIBILITY; NEUROTICISM;

D O I：

10.1007/s12041-011-0037-2

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Data suggest that the serotonin (5-hydroxytryptamine, 5-HT) system is implicated in the pathogenesis of multiple neuropsychiatric disorders and may also be involved in smoking behaviour since nicotine increases brain serotonin secretion. It is known that smoking behaviour is influenced by both genetic and environmental factors. The present review examines the role of the serotonin transporter gene (5-HTT) in smoking behaviour and investigating studies that showed association of 5-HTT gene with smoking. This study discusses a polymorphism which has been investigated by many researchers, as the bi-allelic insertion/deletion polymorphism in the 5'-flanking promoter region (5-HTTLPR). This gene has received considerable attention in attempts to understand the molecular determinants of smoking. Therefore, in the present study, the relationship between genetic polymorphism of serotonin transporter in smoking behaviour is reviewed considering the interactive effect of genetic factors.

引用

页码：179 / 185

页数：7

共 70 条

[1] NEUROTRANSMITTER TRANSPORTERS - RECENT PROGRESS [J].

AMARA, SG ;

KUHAR, MJ .

ANNUAL REVIEW OF NEUROSCIENCE, 1993, 16 :73-93

[2] Chipping away at the genetics of smoking behavior [J].

Amos, Christopher I. ;

Spitz, Margaret R. ;

Cinciripini, Paul .

NATURE GENETICS, 2010, 42 (05) :366-368

[3]

[Anonymous], WORLD HLTH REP 2002

[4] The genetic determinants of smoking [J].

Batra, V ;

Patkar, AA ;

Berrettini, WH ;

Weinstein, SP ;

Leone, FT .

CHEST, 2003, 123 (05) :1730-1739

[5] Presence of multiple functional polyadenylation signals and a single nucleotide polymorphism in the 3′ untranslated region of the human serotonin transporter gene [J].

Battersby, S ;

Ogilvie, AD ;

Blackwood, DHR ;

Shen, SB ;

Muqit, MMK ;

Muir, WJ ;

Teague, P ;

Goodwin, GM ;

Harmar, AJ .

JOURNAL OF NEUROCHEMISTRY, 1999, 72 (04) :1384-1388

[6]

BLAKELY RD, 1994, J EXP BIOL, V196, P263

[7] Preliminary effects of bupropion and the promoter region (HTTLPR) serotonin transporter (SLC6A4) polymorphism on smoking behavior in schizophrenia [J].

Bloch, Boaz ;

Reshef, Alon ;

Cohen, Tamara ;

Tafla, Amos ;

Gathas, Samich ;

Israel, Salomon ;

Gritsenko, Inga ;

Kremer, Ilana ;

Ebstein, Richard P. .

PSYCHIATRY RESEARCH, 2010, 175 (1-2) :38-42

[8]

Blum K, 2000, J PSYCHOACTIVE DRUGS, V32

[9] Associations of the serotonin transporter promoter polymorphism with aggressivity, attention deficit, and conduct disorder in an adoptee population [J].

Cadoret, RJ ;

Langbehn, D ;

Caspers, K ;

Troughton, EP ;

Yucuis, R ;

Sandhu, HK ;

Philibert, R .

COMPREHENSIVE PSYCHIATRY, 2003, 44 (02) :88-101

[10] Serotonin Transporter Genotype and Depressive Symptoms Moderate Effects of Nicotine on Spatial Working Memory [J].

Carlson, Joshua M. ;

Gilbert, David G. ;

Riise, Hege ;

Rabinovich, Norka E. ;

Sugai, Chihiro ;

Froeliger, Brett .

EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY, 2009, 17 (03) :173-180

← 1 2 3 4 5 6 7 →