Spontaneous Regression of an Epidermal Growth Factor Receptor-mutant Left Upper Lobe Adenocarcinoma

被引：0
|
作者：
Schiavon, Marco
Madrid, Andrea Lloret
Pezzuto, Federica
Giraudo, Chiara
Comacchio, Giovanni Maria
Faccioli, Eleonora
Dell'Amore, Andrea
Calabrese, Fiorella
Rea, Federico
机构：
[1] Padova Univ Hosp, Dept Cardiac Thorac Vasc Sci & Publ Hlth, Thorac Surg Div, Padua, Italy
[2] Padova Univ Hosp, Dept Cardiac Thorac Vasc Sci & Publ Hlth, Pathol Div, Padua, Italy
[3] Padova Univ Hosp, Radiol Inst, Dept Med, Padua, Italy
来源：
ANNALS OF THORACIC SURGERY | 2022年 / 114卷 / 04期
关键词：
CIPROFLOXACIN;
D O I：
10.1016/j.athoracsur.2021.11.064
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Spontaneous regression of cancer is a known mani-festation rarely described for thoracic malignancies. We present the case of a patient affected by an epidermal growth factor receptor-mutant adenocarci-noma who developed a contralateral aspiration pneu-monitis months before surgery and manifested a complete pathologic regression without any preopera-tive oncologic treatment. The underlying mechanisms are not clear, but immune system activation appears to be a key player, acting as a plausible trigger of a change in host response to cancer cells. The tumor microenvironment does not appear to be an "inert spectator" but rather an "active protagonist" on the course of the disease and its therapeutic targeting.(Ann Thorac Surg 2022;114:e261-e264) (c) 2022 by The Society of Thoracic Surgeons
引用
收藏
页码：E261 / E264
页数：4
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