Synthesis, crystal structures, and urease inhibition studies of two new Schiff-base copper complexes derived from n-butylamine

被引：13

作者：

Li, Yuguang ^{[1
,2
]}

Li, Zuowen ^{[1
,2
]}

Liu, Yang ^{[1
,2
]}

Dong, Xiongwei ^{[1
,2
]}

Cui, Yongming ^{[1
,2
]}

机构：

[1] Wuhan Text Univ, Sch Chem & Chem Engn, Engn Res Ctr Clean Prod Text Printing, Minist Educ, Wuhan 430073, Peoples R China

[2] Nanjing Univ, State Key Lab Coordinat Chem, Sch Chem & Chem Engn, Nanjing 210093, Jiangsu, Peoples R China

来源：

JOURNAL OF COORDINATION CHEMISTRY | 2012年 / 65卷 / 01期

基金：

中国博士后科学基金;

关键词：

Schiff-base copper(II) complexes; Crystal structures; 5-Chlorosalicylaldehyde; 4-Methoxysalicylaldehyde; Urease inhibitors; JACK-BEAN UREASE; TRANSITION-METAL-COMPLEXES; SOLID-STATE STRUCTURES; MOLECULAR-STRUCTURE; EC; 3.5.1.5; IONS; COORDINATION; CU; CLEAVAGE; LIGANDS;

D O I：

10.1080/00958972.2011.637169

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Two Schiff-base copper(II) complexes, bis(N-n-butyl-5-chlorosalicylaldiminato) copper(II) (1) and bis(N-n-butyl-4-methoxysalicylaldiminato) copper(II) (2), were synthesized and their solid-state structures were determined by X-ray crystallography. Complex 1 displays a distorted square-planar geometry, while 2 possesses square-planar geometry. Copper(II) complexes 1 and 2 showed strong inhibitory activity against jack bean urease (IC50 = 2.7, 3.5 mu mol L-1), compared with acetohydroxamic acid (IC50 = 63.00 mu mol L-1). A molecular modeling study was carried out via the DOCK program to gain understanding of the potent inhibitory activity of these copper species against jack bean urease.

引用

页码：19 / 27

页数：9

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