Positive Association Between Adipose Tissue and Bone Stiffness

被引:27
作者
Berg, R. M. [1 ]
Wallaschofski, H. [1 ]
Nauck, M. [1 ]
Rettig, R. [2 ]
Markus, M. R. P. [3 ,4 ,5 ]
Laqua, R. [6 ]
Friedrich, N. [1 ]
Hannemann, A. [1 ]
机构
[1] Univ Med Greifswald, Inst Clin Chem & Lab Med, D-17475 Greifswald, Germany
[2] Univ Med Greifswald, Inst Physiol, Karlsburg, Germany
[3] Univ Med Greifswald, Dept Internal Med B, D-17475 Greifswald, Germany
[4] Partner Site Greifswald, DZHK German Ctr Cardiovasc Res, Greifswald, Germany
[5] Univ Med Greifswald, Inst Community Med, Dept Study Hlth Pomerania Clin Epidemiol Res, D-17475 Greifswald, Germany
[6] Univ Med Greifswald, Inst Diagnost Radiol & Neuroradiol, D-17475 Greifswald, Germany
关键词
Anthropometric measures; Visceral adipose tissue; Subcutaneous adipose tissue; Quantitative ultrasound; QUANTITATIVE ULTRASOUND PARAMETERS; MINERAL DENSITY; BODY-COMPOSITION; FAT MASS; ABDOMINAL FAT; FRACTURE RISK; LEAN MASS; OBESITY; OSTEOPOROSIS; MEN;
D O I
10.1007/s00223-015-0008-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Obesity is often considered to have a protective effect against osteoporosis. On the other hand, several recent studies suggest that adipose tissue may have detrimental effects on bone quality. We therefore aimed to investigate the associations between body mass index (BMI), waist circumference (WC), visceral adipose tissue (VAT) or abdominal subcutaneous adipose tissue (SAT), and bone stiffness. The study involved 2685 German adults aged 20-79 years, who participated in either the second follow-up of the population-based Study of Health in Pomerania (SHIP-2) or the baseline examination of the SHIP-Trend cohort. VAT and abdominal SAT were quantified by magnetic resonance imaging. Bone stiffness was assessed by quantitative ultrasound (QUS) at the heel (Achilles InSight, GE Healthcare). The individual risk for osteoporotic fractures was determined based on the QUS-derived stiffness index and classified in low, medium, and high risk. Linear regression models, adjusted for sex, age, physical activity, smoking status, risky alcohol consumption, diabetes, and height (in models with VAT or abdominal SAT as exposure), revealed positive associations between BMI, WC, VAT or abdominal SAT, and the QUS variables broadband-ultrasound attenuation or stiffness index. Moreover, BMI was positively associated with speed of sound. Our study shows that all anthropometric measures including BMI and, WC as well as abdominal fat volume are positively associated with bone stiffness in the general population. As potential predictors of bone stiffness, VAT and abdominal SAT are not superior to easily available measures like BMI or WC.
引用
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页码:40 / 49
页数:10
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