STUDIES TOWARDS THE N-ACYLATIVE KINETIC RESOLUTION OF NOBIN

被引：16

作者：

Arseniyadis, Stellios ^{[1
]}

Mahesh, Mohan ^{[1
]}

McDaid, Paul ^{[1
]}

Hampel, Thomas ^{[1
]}

Davey, Stephen G. ^{[1
]}

Spivey, Alan C. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

来源：

COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | 2011年 / 76卷 / 10期

基金：

英国工程与自然科学研究理事会;

关键词：

Kinetic resolution; Atropisomerism; Asymmetric synthesis; Organocatalysis; NUCLEOPHILIC AROMATIC-SUBSTITUTION; 2-COMPONENT MOLECULAR-CRYSTAL; 1-NAPHTHYL GRIGNARD-REAGENTS; ENANTIOSELECTIVE ACYLATION; ASYMMETRIC CATALYSIS; FACILE SYNTHESIS; DERIVATIVES; 2-AMINO-2'-HYDROXY-1,1'-BINAPHTHYL; 2-NAPHTHOL; EFFICIENT;

D O I：

10.1135/cccc2011034

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An investigation into the N-acylation of atropisomeric anilines 8 and 2, which are related to NOBIN (1), catalysed by small molecule chiral pyridine-based nucleophilic catalysts is described. The first organocatalytic kinetic resolution (KR) of an atropisomeric aniline is described.

引用

页码：1239 / 1253

页数：15

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