Staphylococcus aureus: an underestimated factor in the pathogenesis of atopic dermatitis?

被引：48
|
作者：
Blicharz, Leszek [1 ]
Rudnicka, Lidia [1 ]
Samochocki, Zbigniew [1 ]
机构：
[1] Med Univ Warsaw, Dept Dermatol, 82 A Koszykowa St, PL-05077 Warsaw, Poland
来源：
POSTEPY DERMATOLOGII I ALERGOLOGII | 2019年 / 36卷 / 01期
关键词：
atopic dermatitis; pathogenesis; Staphylococcus aureus; PHENOL-SOLUBLE MODULINS; SUSCEPTIBILITY LOCI; SKIN COLONIZATION; BIOFILM FORMATION; DISEASE SEVERITY; IMMUNE-RESPONSE; EPIDERMIDIS; BACTERIAL; BARRIER; ECZEMA;
D O I：
10.5114/ada.2019.82821
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Atopic dermatitis is a common, recurrent pruritic dermatosis with a complex pathogenesis. It has been associated with disordered patterns of immunological response and impaired epithelial barrier integrity. These features predispose the patients to robust colonization of skin lesions by Staphylococcus aureus. Virulence factors of S. aureus (e.g. superantigens, alpha- and delta-toxin, protein A) have been shown to exacerbate and perpetuate the course of atopic dermatitis. Novel therapeutic options with potential for restoring natural microbiome composition are being elaborated and may enter clinical practice in the future.
引用
收藏
页码：11 / 17
页数：7
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