Global and regional molecular epidemiology of HIV-1, 1990-2015: a systematic review, global survey, and trend analysis

被引：159

作者：

Hemelaar, Joris ^{[1
]}

Elangovan, Ramyiadarsini ^{[1
]}

Yun, Jason ^{[1
]}

Dickson-Tetteh, Leslie ^{[1
]}

Fleminger, Isabella ^{[1
]}

Kirtley, Shona ^{[2
]}

Williams, Brian ^{[3
]}

Gouws-Williams, Eleanor ^{[4
]}

Ghys, Peter D. ^{[5
]}

Abimiku, Alash'le G. ^{[6
]}

Agwale, Simon ^{[7
]}

Archibald, Chris ^{[8
]}

Avidor, Boaz ^{[9
]}

Gabriela Barbas, Maria ^{[10
]}

Barre-Sinoussi, Francoise ^{[11
]}

Barugahare, Banson ^{[12
]}

Belabbes, El Hadj ^{[13
]}

Bertagnolio, Silvia ^{[14
]}

Birx, Deborah ^{[15
]}

Bobkov, Aleksei F. ^{[16
]}

Brandful, James ^{[17
]}

Bredell, Helba ^{[18
]}

Brennan, Catherine A. ^{[19
]}

Brooks, James ^{[8
]}

Bruckova, Marie ^{[20
]}

Buonaguro, Luigi ^{[21
]}

Buonaguro, Franco ^{[21
]}

Butto, Stefano ^{[22
]}

Buve, Anne ^{[23
]}

Campbell, Mary ^{[24
]}

Carr, Jean ^{[6
]}

Carrera, Alex ^{[25
]}

Gomez Carrillo, Manuel ^{[26
]}

Celum, Connie ^{[24
]}

Chaplin, Beth ^{[27
]}

Charles, Macarthur ^{[28
]}

Chatzidimitriou, Dimitrios ^{[29
]}

Chen, Zhiwei ^{[30
]}

Chijiwa, Katsumi ^{[31
]}

Cooper, David ^{[32
]}

Cunningham, Philip ^{[25
]}

Dagnra, Anoumou ^{[33
]}

de Gascun, Cillian F. ^{[34
]}

Del Amo, Julia ^{[35
]}

Delgado, Elena ^{[35
]}

Dietrich, Ursula ^{[36
]}

Dwyer, Dominic ^{[37
]}

Ellenberger, Dennis ^{[38
]}

Ensoli, Barbara ^{[22
]}

Essex, Max ^{[39
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Womens Ctr, Nuffield Dept Womens & Reprod Hlth, Oxford OX3 9DU, England

[2] Univ Oxford, Botnar Res Ctr, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Ctr Stat Med, Oxford, England

[3] Stellenbosch Univ, South African Ctr Epidemiol Modelling & Anal, Stellenbosch, South Africa

[4] UNAIDS, Fast Track Implementat Dept, Geneva, Switzerland

[5] UNAIDS, Strateg Informat Dept, Geneva, Switzerland

[6] Univ Maryland, Inst Human Virol, Baltimore, MD 21201 USA

[7] Gede Fdn, Abuja, Nigeria

[8] Publ Hlth Agcy Canada, Ottawa, ON, Canada

[9] Tel Aviv Sourasky Med Ctr, Tel Aviv, Israel

[10] Minist Salud, Cordoba, Argentina

[11] Inst Pasteur, Paris, France

[12] Minist Hlth, Entebbe, Uganda

[13] Inst Pasteur, Natl Reference Lab HIV AIDS, Algiers, Algeria

[14] WHO, Geneva, Switzerland

[15] Off Global AIDS Coordinator, Washington, DC USA

[16] DI Ivanovskii Inst Virol, Moscow, Russia

[17] Univ Ghana, Noguchi Mem Inst Med Res, Accra, Ghana

[18] Univ Cape Town, Cape Town, South Africa

[19] Abbott Labs, Chicago, IL USA

[20] Natl Inst Publ Hlth, Prague, Czech Republic

[21] Natl Canc Inst Fdn G Pascale, AIDS Reference Ctr, Naples, Italy

[22] Ist Super Sanita, Natl AIDS Ctr, Rome, Italy

[23] Inst Trop Med, Antwerp, Belgium

[24] Univ Washington, Sch Med, Seattle, WA USA

[25] St Vincents Hosp, Sydney, NSW, Australia

[26] Univ Buenos Aires, Buenos Aires, DF, Argentina

[27] Harvard TH Chan Sch Publ Hlth, Boston, MA USA

[28] Gheskio Ctr, Port Au Prince, Haiti

[29] Aristotle Univ Thessaloniki, Thessaloniki, Greece

[30] Chinese Acad Med Sci, Peking Union Med Sch, Beijing, Peoples R China

[31] Kyushu Univ Hosp, Fukuoka Inst Hlth & Environm Sci, Dazaifu, Japan

[32] Kirby Inst, Sydney, NSW, Australia

[33] Univ Lome, Fac Sci Sante, Lome, Togo

[34] Univ Coll Dublin, Dublin, Ireland

[35] Inst Salud Carlos III, Madrid, Spain

[36] Georg Speyer Haus, Chemotherapeut Forschungsinstitut, Frankfurt, Germany

[37] Westmead Hosp, Pathol West, Westmead, NSW, Australia

[38] Ctr Dis Control & Prevent, Atlanta, GA USA

[39] Harvard Sch Publ Hlth, Boston, MA USA

[40] Duke Univ, Med Ctr, Durham, NC USA

[41] Univ Bordeaux, Bordeaux, France

[42] Montpellier Univ Hosp, Montpellier, France

[43] Natl AIDS Res Inst, Pune, Maharashtra, India

[44] Complejo Hosp Univ Granada, Granada, Spain

[45] Royal Prince Alfred Hosp, Sydney, NSW, Australia

[46] WHO, HIV Lab Programme AIDS AFRO, Ouagadougou, Burkina Faso

[47] London Sch Hyg & Trop Med, London, England

[48] UCL, London, England

[49] Minist Hlth, Natl HIV Reference Lab, Tel Aviv, Israel

[50] Fiocruz MS, Inst Oswaldo Cruz, Rio De Janeiro, Brazil

来源：

LANCET INFECTIOUS DISEASES | 2019年 / 19卷 / 02期

关键词：

VACCINE; DIVERSITY; SUBTYPES; MULTICENTER; INFECTION;

D O I：

10.1016/S1473-3099(18)30647-9

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background Global genetic diversity of HIV-1 is a major challenge to the development of HIV vaccines. We aimed to estimate the regional and global distribution of HIV-1 subtypes and recombinants during 1990-2015. Methods We searched PubMed, EMBASE (Ovid), CINAHL (Ebscohost), and Global Health (Ovid) for HIV-1 subtyping studies published between Jan 1, 1990, and Dec 31, 2015. We collected additional unpublished HIV-1 subtyping data through a global survey. We included prevalence studies with HIV-1 subtyping data collected during 1990-2015. We grouped countries into 14 regions and analysed data for four time periods (1990-99, 2000-04, 2005-09, and 2010-15). The distribution of HIV-1 subtypes, circulating recombinant forms (CRFs), and unique recombinant forms (URFs) in individual countries was weighted according to the UNAIDS estimates of the number of people living with HIV (PLHIV) in each country to generate regional and global estimates of HIV-1 diversity in each time period. The primary outcome was the number of samples designated as HIV-1 subtypes A, B, C, D, F, G, H, J, K, CRFs, and URFs. The systematic review is registered with PROSPERO, number CRD42017067164. Findings This systematic review and global survey yielded 2203 datasets with 383 519 samples from 116 countries in 1990-2015. Globally, subtype C accounted for 46 . 6% (16 280 897/34 921 639 of PLHIV) of all HIV-1 infections in 2010-15. Subtype B was responsible for 12 . 1% (4 235 299/34 921 639) of infections, followed by subtype A (10 . 3%; 3 587 003/34 921 639), CRF02_AG (7 . 7%; 2 705 110/34 921 639), CRF01_AE (5 . 3%; 1 840 982/34 921 639), subtype G (4 . 6%; 1 591 276/34 921 639), and subtype D (2 . 7%; 926 255/34 921 639). Subtypes F, H, J, and K combined accounted for 0 . 9% (311 332/34 921 639) of infections. Other CRFs accounted for 3 . 7% (1 309 082/34 921 639), bringing the proportion of all CRFs to 16 . 7% (5 844 113/34 921 639). URFs constituted 6 . 1% (2 134 405/34 921 639), resulting in recombinants accounting for 22 . 8% (7 978 517/34 921 639) of all global HIV-1 infections. The distribution of HIV-1 subtypes and recombinants changed over time in countries, regions, and globally. At a global level during 2005-15, subtype B increased, subtypes A and D were stable, and subtypes C and G and CRF02_AG decreased. CRF01_AE, other CRFs, and URFs increased, leading to a consistent increase in the global proportion of recombinants over time. Interpretation Global and regional HIV diversity is complex and evolving, and is a major challenge to HIV vaccine development. Surveillance of the global molecular epidemiology of HIV-1 remains crucial for the design, testing, and implementation of HIV vaccines.

引用

页码：143 / 155

页数：13

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