Circulating microRNAs: Association with disease and potential use as biomarkers

被引：366
作者：
Reid, Glen [1 ]
Kirschner, Michaela B. [1 ]
van Zandwijk, Nico [1 ]
机构：
[1] Univ Sydney, ADRI, Bernie Banton Ctr, Sydney, NSW 2139, Australia
来源：
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2011年 / 80卷 / 02期
关键词：
microRNAs; Plasma; Serum; Microvesicles; Exosomes; Biomarkers; REAL-TIME PCR; EXPRESSION PROFILES; DIAGNOSTIC MARKER; DOWN-REGULATION; SERUM; CANCER; PLASMA; RNA; SIGNATURES; EXOSOMES;
D O I：
10.1016/j.critrevonc.2010.11.004
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The control of gene expression by microRNAs influences many cellular processes and has been implicated in the control of many (patho)physiological states. Recently, microRNAs have been detected in serum and plasma, and circulating microRNA profiles have now been associated with a range of different tumour types, diseases such as stroke and heart disease, as well as altered physiological states such as pregnancy. Here we review the disease-specific profiles of circulating microRNAs, and the methodologies used for their detection and quantification. We also discuss possible functions of circulating microRNAs and their potential as non-invasive biomarkers. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：193 / 208
页数：16
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