A single mRNA vaccine dose in COVID-19 patients boosts neutralizing antibodies against SARS-CoV-2 and variants of concern

被引：14

作者：

van Gils, Marit J. ^{[1
]}

van Willigen, Hugo D. G. ^{[1
]}

Wynberg, Elke ^{[1
,2
]}

Han, Alvin X. ^{[1
]}

van der Straten, Karlijn ^{[1
,3
]}

Burger, Judith A. ^{[1
]}

Poniman, Meliawati ^{[1
]}

Oomen, Melissa ^{[1
]}

Tejjani, Khadija ^{[1
]}

Bouhuijs, Joey H. ^{[1
]}

Verveen, Anouk ^{[4
]}

Lebbink, Romy ^{[2
]}

Dijkstra, Maartje ^{[2
,3
]}

Appelman, Brent ^{[5
]}

Lavell, A. H. Ayesha ^{[6
]}

Caniels, Tom G. ^{[1
]}

Bontjer, Ilja ^{[1
]}

van Vught, Lonneke A. ^{[5
,7
]}

Vlaar, Alexander P. J. ^{[7
]}

Sikkens, Jonne J. ^{[6
]}

Bomers, Marije K. ^{[6
]}

Russell, Colin A. ^{[1
]}

Kootstra, Neeltje A. ^{[9
]}

Sanders, Rogier W. ^{[1
,8
]}

Prins, Maria ^{[2
,3
]}

de Bree, Godelieve J. ^{[3
]}

de Jong, Menno D. ^{[1
]}

机构：

[1] Univ Amsterdam, Amsterdam Inst Infect & Immun, Dept Med Microbiol & Infect Prevent, Amsterdam UMC, Amsterdam, Netherlands

[2] GGD, Dept Infect Dis, Publ Hlth Serv Amsterdam, Amsterdam, Netherlands

[3] Univ Amsterdam, Amsterdam Inst Infect & Immun, Dept Internal Med, Amsterdam UMC, Amsterdam, Netherlands

[4] Univ Amsterdam, Amsterdam Sch Publ Hlth, Dept Med Psychol, Amsterdam UMC, Amsterdam, Netherlands

[5] Univ Amsterdam, Ctr Expt & Mol Med, Amsterdam Inst Infect & Immun, Amsterdam UMC, Amsterdam, Netherlands

[6] Vrije Univ Amsterdam, Amsterdam Inst Infect & Immun, Dept Internal Med, Amsterdam UMC, Amsterdam, Netherlands

[7] Univ Amsterdam, Amsterdam Inst Infect & Immun, Dept Intens Care Med, Amsterdam UMC, Amsterdam, Netherlands

[8] Cornell Univ, Dept Microbiol & Immunol, Weill Med Coll, New York, NY 10021 USA

[9] Univ Amsterdam, Amsterdam Inst Infect & Immun, Dept Expt Immunol, Amsterdam UMC, Amsterdam, Netherlands

来源：

CELL REPORTS MEDICINE | 2022年 / 3卷 / 01期

基金：

欧洲研究理事会;

关键词：

SEX-DIFFERENCES; INFECTION;

D O I：

10.1016/j.xcrm.2021.100486

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The urgent need for, but limited availability of, SARS-CoV-2 vaccines worldwide has led to widespread consideration of dose-sparing strategies. Here, we evaluate the SARS-CoV-2-specific antibody responses following BNT162b2 vaccination in 150 previously SARS-CoV-2-infected individuals from a population-based cohort. One week after first vaccine dose, spike protein antibody levels are 27-fold higher and neutralizing antibody titers 12-fold higher, exceeding titers of fully vaccinated SARS-CoV-2-naive controls, with minimal additional boosting after the second dose. Neutralizing antibody titers against four variants of concern increase after vaccination; however, overall neutralization breadth does not improve. Pre-vaccination neutralizing antibody titers and time since infection have the largest positive effect on titers following vaccination. COVID-19 severity and the presence of comorbidities have no discernible impact on vaccine response. In conclusion, a single dose of BNT162b2 vaccine up to 15 months after SARS-CoV-2 infection offers higher neutralizing antibody titers than 2 vaccine doses in SARS-CoV-2-naive individuals.

引用

页数：13

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