Total synthesis of clavosolide A via tandem allylic oxidation/oxa-conjugate addition reaction

被引：7
|
作者：
Baker, Joseph B. [1 ]
Kim, Hyoungsu [2 ]
Hong, Jiyong [1 ]
机构：
[1] Duke Univ, Dept Chem, Durham, NC 27708 USA
[2] Ajou Univ, Coll Pharm, Suwon 443749, South Korea
来源：
TETRAHEDRON LETTERS | 2015年 / 56卷 / 23期
关键词：
Clavosolide; Total synthesis; Tandem reaction; Oxa-conjugate addition; gem-Disubstituent effect; Tetrahydropyran; NATURAL-PRODUCT (-)-CLAVOSOLIDE-A; STEREOSELECTIVE-SYNTHESIS; ABSOLUTE-CONFIGURATION; BENZOIC ANHYDRIDE; FORMAL SYNTHESIS; LACTONES; ESTERS;
D O I：
10.1016/j.tetlet.2014.11.135
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The tandem allylic oxidation/oxa-conjugate addition reaction promoted by the gem-disubstituent effect in conjunction with the NHC-mediated oxidative esterification was explored for the facile synthesis of clavosolide A. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3120 / 3122
页数：3
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