Design of a new oligotriazole peptide nucleic acid analogue (oT-PNA)

被引：8

作者：

Vergnaud, Julien ^{[1
]}

Faugeras, Pierre-Antoine ^{[1
]}

Chaleix, Vincent ^{[1
]}

Champavier, Yves ^{[2
]}

Zerrouki, Rachida ^{[1
]}

机构：

[1] Fac Sci & Tech, Lab Chim Subst Nat EA1069, F-87060 Limoges, France

[2] Univ Limoges, Serv Commun RMN, Fac Pharm, F-87025 Limoges, France

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 46期

关键词：

Peptide nucleic acid; Click chemistry; Microwave chemistry; Synthesis design; MICROWAVE-ASSISTED SYNTHESIS; CLICK CHEMISTRY; TERMINAL ALKYNES; DNA; OLIGONUCLEOTIDES; CYCLOADDITION; INHIBITORS; LIGATION; THYMINE; AZIDES;

D O I：

10.1016/j.tetlet.2011.09.050

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe in this Letter the synthesis of an original thymine azido-heterotrimer generated by Click Chemistry. This trimer has been obtained from an azido-thymidine and a new chloroethyl-propargylated PNA monomer analogue, after two azidation/click-reaction cycles. Conformational preferences of a rotameric intermediate have also been studied (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：6185 / 6189

页数：5

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